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Neurotoxins as Preclinical Models for Parkinson’s Disease
(Springer New York LLC, 2018)
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.Translational medicine is one of the major concerns in this century. While significant advances have been made with scientific knowledge, the translation ...
Changes in neural circuitry associated with depression at pre-clinical, pre-motor and early motor phases of Parkinson's disease
(Elsevier Ltd, 2017)
© 2016 Elsevier Ltd Although Parkinson's Disease (PD) is mostly considered a motor disorder, it can present at early stages as a non-motor pathology. Among the non-motor clinical manifestations, depression shows a high ...
Preclinical evaluation of the encelia canescens lam extract: Medicinal properties useful for cancer treatment
(Informatics Publishing Limited, 2015)
© 2015, Informatics Publishing Limited. All rights reserved. Encelia canescens Lam (nv: mancapaqi, mataloba, matalobo, mucle, or “coronilla de fraile”) is a 30-80-cm high shrubby perennial plant that grows in the Atacama ...
Humanized mouse models of rheumatoid arthritis for studies on immunopathogenesis and preclinical testing of cell-based therapies
(Frontiers Media S.A., 2019)
Copyright © 2019 Schinnerling, Rosas, Soto, Thomas and Aguillón. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other ...
Preclinical evaluation of the efficacy of antivenoms for snakebite envenoming: State-of-the-art and challenges ahead
(2017-05)
Animal-derived antivenoms constitute the mainstay in the therapy of snakebite envenoming. The efficacy of antivenoms to neutralize toxicity of medically-relevant snake venoms has to be demonstrated through meticulous ...
Preclinical evaluation of the efficacy of antivenoms for snakebite envenoming: State-of-the-art and challenges ahead
(2017-05)
Animal-derived antivenoms constitute the mainstay in the therapy of snakebite envenoming. The efficacy of antivenoms to neutralize toxicity of medically-relevant snake venoms has to be demonstrated through meticulous ...
The importance of choosing a preclinical model that reflects what happens in Parkinson's disease
(Elsevier Ltd, 2019)
One of the major problems in the translation of successful preclinical results to clinical studies and new therapies in Parkinson's disease is the use of preclinical models based on exogenous neurotoxins that do not replicate ...
GLP-1 and GIP receptor agonists in the treatment of Parkinson’s disease: Translational systematic review and meta-analysis protocol of clinical and preclinical studies
(2021-08-01)
Background Parkinson’s disease (PD) is a progressive multifactorial neurodegenerative condition. Epidemiological studies have shown that patients with type 2 diabetes mellitus (T2DM2) are at increased risk for developing ...
Sleep and epilepsy: Exploring an intriguing relationship with a translational approach
(Elsevier B.V., 2013-03-01)
The relationship between sleep and epilepsy has been well established. There is a high prevalence of sleep disturbances in epilepsy, which are associated with a decreased quality of life of individuals with epilepsy. in ...
A case study to explore how medical students learn linguistic cognitive skills during preclinical training
Background: Communicative competences are considered central aspects of the medical profession but are often reduced to the physician-patient relationship. Little attention has been given to teaching the linguistic cognitive ...