Buscar
Mostrando ítems 1-10 de 98
QSAR on aryl-piperazine derivatives with activity on malaria
(Elsevier Science, 2012-01-15)
In this work we offer linear regression models on a set of aryl-piperazine derivatives that are obtained by exploring a pool containing 1497 Dragon molecular descriptors, in order to establish the best relationships linking ...
Synthesis, 5-hydroxytryptamine1A receptor affinity and docking studies of 3-[3-(4-aryl-1-piperazinyl)-propyl]-1H-indole derivatives
(Pharmaceutical Society of Japan, 2012)
Three-Dimensional Quantitative Structure-Activity Relationships (3D-QSAR) on a Series of Piperazine-Carboxamides Fatty Acid Amide Hydrolase (FAAH) Inhibitors as a Useful Tool for the Design of New Cannabinoid Ligands
(2019)
Fatty Acid Amide Hydrolase (FAAH) is one of the main enzymes responsible for endocannabinoid metabolism. Inhibition of FAAH increases endogenous levels of fatty acid ethanolamides such as anandamide (AEA) and thus consitutes ...
Current status and progress made in malaria chemotherapy
(Bentham Science Publishers, 2007-02)
Malaria is the most important parasitic disease worldwide, affecting more than 500 million people and causing close to 1 million deaths per annum. This serious fact is mainly attributable to the emergence of drug resistant ...
Reações entre (e)-5-bromo-1,1,1-trialo-4-metoxipent-3-en-2-onas e aminoácidos para produção de heterociclos de 5, 6 e 7 membros
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2022-05-13)
This work present the versatility of 4-alkoxy-5-bromo-1,1,1-trialopent-3-en-2-ones in reactions with amino acids, exploring the four reactive centers of this building block and leading to the formation of heterocycles of ...