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Phenothiazine molecule provides the basic chemical structure for various classes of pharmacotherapeutic agents
The chemical structure of phenothiazine provides a most valuable molecular template for the development of agents able to interact with a wide variety of biological processes. Synthetic phenothiazines (with aliphatic, ...
In vitro human plasma leucine5-enkephalin degradation is inhibited by a select number of drugs with the phenothiazine molecule in their chemical structure
A number of drugs with the phenothiazine molecule in their chemical structure inhibit in a dose-dependent manner human plasmatic aminopeptidase leucine5-enkephalin (LEU) metabolism. Half-life peptide degradation was ...
Inhibition by phenothiazine derivatives of the adenylate cyclase of amphibian oocytes
The adenylate cyclase activity of membranes of Xenopus laevis oocytes and follicle cells was affected by the presence of 2-chloro-10-(3-aminopropyl)phenothiazine (CAPP) and two other antipsychotic drugs, fluphenazine and ...
Properties of a cyclic nucleotide phosphodiesterase of amphibian oocytes that is activated by calmodulin and calcium, by tryptic proteolysis, and by phospholipids
A calmodulin-Ca2+-stimulated cyclic nucleotide phosphodiesterase (EC 220.127.116.11) which hydrolyzed both cGMP and cAMP has been purified about 2000-fold from ovaries of the amphibian Xenopus laevis. Gel filtration through ...