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Predicting binding modes of reversible peptide-based inhibitors of falcipain-2 consistent with structure-activity relationships
(Wiley-Blackwell, 2017-09-01)
Falcipain-2 ( FP-2) is a major hemoglobinase of Plasmodium falciparum, considered an important drug target for the development of antimalarials. A previous study reported a novel series of 20 reversible peptide-based ...
Peptide and peptide-based inhibitors of SARS-CoV-2 entry
To date, no effective vaccines or therapies are available against the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), the causative pandemic agent of coronavirus disease
2019 (COVID-19). Due to their safety, ...
Molecular Dynamics Simulations of Peptide Inhibitors Complexed With Trypanosoma cruzi Trypanothione Reductase
(2012)
The drugs against tropical neglected diseases, especially Chagas’ Disease, were launched more than 30 years ago, and the development of resistance requires the discovery of new and more effective chemotherapeutic agents. ...
Rational design and synthesis of modified natural peptides from Boana pulchella (anura) as acetylcholinesterase inhibitors and antioxidants
(Springer, 2021-11)
The use of acetylcholinesterase (AChE) inhibitors, antioxidants or multitarget compounds are among the main strategies against Alzheimer’s disease (AD). Between AChE inhibitors, those targeting the peripheral anionic site ...
Non-toxic dimeric peptides derived from the bothropstoxin-I are potent SARS-CoV-2 and papain-like protease inhibitors
(2021-08-02)
The COVID-19 outbreak has rapidly spread on a global scale, affecting the economy and public health systems throughout the world. In recent years, peptide-based therapeutics have been widely studied and developed to treat ...
Discovery of a Beetroot Protease Inhibitor to Identify and Classify Plant-Derived Cystine Knot Peptides
(2020-11-25)
Plant peptide protease inhibitors are important molecules in seed storage metabolism and to fight insect pests. Commonly they contain multiple disulfide bonds and are exceptionally stable molecules. In this study, a novel ...
Design and synthesis of peptides from bacterial ParE toxin as inhibitors of topoisomerases
(Elsevier France-editions Scientifiques Medicales Elsevier, 2012-08-01)
Toxin-antitoxin (TA) proteic systems encode a toxin and an antitoxin that regulate the growth and death of bacterial cells under various stress conditions. The ParE protein is a toxin that inhibits DNA gyrase activity and ...
Design and synthesis of peptides from bacterial ParE toxin as inhibitors of topoisomerases
(Elsevier France-editions Scientifiques Medicales Elsevier, 2012-08-01)
Toxin-antitoxin (TA) proteic systems encode a toxin and an antitoxin that regulate the growth and death of bacterial cells under various stress conditions. The ParE protein is a toxin that inhibits DNA gyrase activity and ...
Peptides based on CcdB protein as novel inhibitors of bacterial topoisomerases
(Pergamon-Elsevier B.V. Ltd, 2008-12-01)
The ccd toxin-antitoxin system of the F plasmid encodes CcdB, a protein that poisons the essential Escherichia coli DNA gyrase, unique type IIA topoisomerase able to introduce negative supercoils into DNA. Based on CcdB ...
Peptides based on CcdB protein as novel inhibitors of bacterial topoisomerases
(Pergamon-Elsevier B.V. Ltd, 2008-12-01)
The ccd toxin-antitoxin system of the F plasmid encodes CcdB, a protein that poisons the essential Escherichia coli DNA gyrase, unique type IIA topoisomerase able to introduce negative supercoils into DNA. Based on CcdB ...