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Penicillium chrysogenum, a vintage model with a cutting-edge profile in biotechnology
(MDPI, 2022)
The discovery of penicillin entailed a decisive breakthrough in medicine. No other medical advance has ever had the same impact in the clinical practise. The fungus Penicillium chrysogenum (reclassified as P. rubens) has ...
Influence of activation on the multipoint immobilization of penicillin G acylase on macroporous silica
(Brazilian Society of Chemical Engineering, 1999-06-01)
Penicillin G acylase is the second most important enzyme used by industry in an immobilized form. Penicillin hydrolysis is its main application. This reaction is used to produce 6-aminopenicillanic acid (6-APA), an ...
Influence of activation on the multipoint immobilization of penicillin G acylase on macroporous silica
(Brazilian Society of Chemical Engineering, 1999-06-01)
Penicillin G acylase is the second most important enzyme used by industry in an immobilized form. Penicillin hydrolysis is its main application. This reaction is used to produce 6-aminopenicillanic acid (6-APA), an ...
EFEITO DE SURFACTANTES NA ESTABILIDADE DE COMPOSTOS DE USO TERAPEUTICO
(1990-12-01)
A critical revision of literature as regards to the drug stability in the presence of surfactants were realized. The functional groups envolved in the drug decomposition were used to the development of the discussion. The ...
EFEITO DE SURFACTANTES NA ESTABILIDADE DE COMPOSTOS DE USO TERAPEUTICO
(1990-12-01)
A critical revision of literature as regards to the drug stability in the presence of surfactants were realized. The functional groups envolved in the drug decomposition were used to the development of the discussion. The ...
Influence of activation on the multipoint immobilization of penicillin G acylase on macroporous silica
(Brazilian Society of Chemical Engineering, 2014)
Motifs in the C-terminal region of the Penicillium chrysogenum ACV synthetase are essential for valine epimerization and processivity of tripeptide formation
(2012)
The first step in the penicillin biosynthetic pathway is the non-ribosomal condensation of l-α-aminoadipic acid, l-cysteine and l-valine into the tripeptide δ-(l-α-aminoadipyl)-l-cysteinyl-d-valine (ACV). This reaction is ...
Easily handling penicillin G acylase magnetic cross-linked enzymes aggregates: Catalytic and morphological studies
(Elsevier B.V., 2014-01-01)
Biomolecules labeled with superparamagnetic nanoparticles can be selectively removed from complex reaction mixtures using an external magnetic field. Amino-functionalized superparamagnetic iron oxide nanoparticles (amino-SPION) ...