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Pharmacological models and approaches for pathophysiological conditions associated with hypoxia and oxidative stress
(Pergamon-Elsevier, 2016)
Hypoxia is the failure of oxygenation at the tissue level,where the reduced oxygen delivered is not enough to satisfy
tissue demands. Metabolic depression is the physiological adaptation associated with reduced oxygen ...
Nuclear factor-kappaB: A main regulator of inflammation and cell survival in endometriosis pathophysiology
(2012)
Objective: To update, analyze, and summarize the literature concerning nuclear factor-kappaB (NF-κB) participation in endometriosis pathophysiology. Design: Review. Result(s): Nuclear factor-kappaB is physiologically ...
Obesity and Preeclampsia. Common Pathophysiological Mechanisms
(Frontiers in PhysiologyUSA, 2018-12-19)
Preeclampsia is a disorder specific of the human being that appears after 20 weeks
of pregnancy, characterized by new onset of hypertension and proteinuria. Abnormal
placentation and reduced placental perfusion associated ...
Hiponatremia
(Hospital Clínico Universidad de Chile, 2012)
Alterations in plasma osmolality are related to changes in cell volume, which are the
pathophysiological substrate of serious diseases. Under normal conditions sodium
is the main determinant of plasma osmolality, and ...
Late esophagogastric anatomic and functional changes after sleeve gastrectomy and its clinical consequences with regards to gastroesophageal reflux disease
(NLM (Medline), 2019)
Gastroesophageal reflux disease (GERD) is described as a complication after sleeve gastrectomy. Most studies have used only clinical symptoms or upper gastrointestinal endoscopy for evaluation of reflux after surgery. ...
Pathophysiology of Ischemic Stroke: Role of Oxidative Stress
(Bentham Science, U Arab Emirates, 2020)
Stroke is the second leading cause of mortality and the major cause of adult physical disability worldwide. The currently available treatment to recanalize the blood flow in acute ischemic stroke is intravenous administration ...
Influence of BDNF Genetic Polymorphisms in the Pathophysiology of Aging-related Diseases
(Int Soc Aging & Disease, 2020)
For the first time in history, most of the population has a life expectancy equal or greater than 60 years. By the year 2050, it is expected that the world population in that age range will reach 2000 million, an increase ...
Prion function and pathophysiology in non-mammalian models
(Bentham Science Publishers B.V., 2017)
© 2017 Bentham Science Publishers. More than thirty years have passed since the discovery of the prion protein (PrP) and its causative role in transmissible spongiform encephalopathy. Since a combination of both gain- and ...
Implications of oxidative stress in the pathophysiology of obstructive uropathy
(2009)
Although the functional and clinical alterations occurring in patients with obstructive uropathy are not well understood, it has been suggested that oxidative stress could contribute in the mechanism responsible for the ...