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The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability
(2019)
The coordinated movement of organisms relies on efficient nerve-muscle communication at the neuromuscular junction. After peripheral nerve injury or neurodegeneration, motor neurons and Schwann cells increase the expression ...
The p75(NTR) neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability
(2019)
The coordinated movement of organisms relies on efficient nerve-muscle communication at the neuromuscular junction. After peripheral nerve injury or neurodegeneration, motor neurons and Schwann cells increase the expression ...
p75 NTR expression is induced in isolated neurons of the penumbra after ischemia by cortical devascularization
(Wiley-liss, div John Wiley & Sons Inc., 2009-10)
The p75 neurotrophin receptor (p75NTR) is involved in neuronal functions going from induction of apoptosis and growth inhibition to the promotion of survival. p75NTR expression is induced in central nervous system (CNS) ...
p75NTR and its ligand proNGF activate paracrine mechanisms etiological to the vascular, inflammatory, and neurodegenerative pathologies of diabetic retinopathy
(Society for Neuroscience, 2016-08)
In many diseases, expression and ligand-dependent activity of the p75NTR receptor can promote pericyte and vascular dysfunction, inflammation, glial activation, and neurodegeneration. Diabetic retinopathy (DR) is characterized ...
proBDNF and p75NTR control excitability and persistent firing of cortical pyramidal neurons
(Society for Neuroscience, 2015-07)
Persistent firing of entorhinal cortex (EC) pyramidal neurons is a key component of working and spatial memory. We report here that a pro-brain-derived neurotrophic factor (proBDNF)-dependent p75NTR signaling pathway plays ...
Myelin-associated glycoprotein modulates apoptosis of motoneurons during early postnatal development via NgR/p75 NTR receptor-mediated activation of RhoA signaling pathways
(Nature Publishing Group, 2015-09)
Myelin-associated glycoprotein (MAG) is a minor constituent of nervous system myelin, selectively expressed on the periaxonal myelin wrap. By engaging multiple axonal receptors, including Nogo-receptors (NgRs), MAG exerts ...
p75NTR antagonists attenuate photoreceptor cell loss in murine models of retinitis pigmentosa
(Nature Publishing Group, 2017-07)
ProNGF signaling through p75NTR has been associated with neurodegenerative disorders. Retinitis pigmentosa (RP) comprises a group of inherited retinal dystrophies that causes progressive photoreceptor cell degeneration and ...
Nerve growth factor induces cell cycle arrest of astrocytes
(John Wiley & Sons Inc, 2012-06)
Neurotrophins can influence multiple cellular functions depending on the cellular context and the specific receptors they interact with. These neurotrophic factors have been extensively studied for their ability to support ...