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Nitroxyl (azanone) trapping by metalloporphyrins
(Elsevier Science Sa, 2011-12)
The present review starts describing nitroxyl (azanone, 1HNO) biological relevance, in relation with NO physiology, from a chemical reactivity perspective. After a description of commonly used azanone donors and their ...
QM-MM investigation of the reaction products between nitroxyl and O2 in aqueous solution
(Elsevier Science, 2008-09)
By means of combined quantum-classical molecular (QM/MM) dynamics simulations, we investigated the structural properties and the vibrational spectra in aqueous solution of four possible intermediate species of the oxidation ...
Tracking nitroxyl-derived posttranslational modifications of phospholamban in cardiac myocytes
(Rockefeller University Press, 2019-04-22)
Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Calcium (Ca2+) mishandling is one of the most striking abnormalities in this wide spectrum of pathologies, among which heart failure (HF) ...
Water-Soluble Nitroxyl Porphyrin Complexes FeIITPPSHNO and FeIITPPSNO- Obtained from Isolated FeIITPPSNO·
(American Chemical Society, 2019-10)
The first biomimetic water soluble FeII-porphyrin nitroxyl complexes were obtained and characterized by UV-Vis in protonated and deprotonated forms by reduction of previously isolated and characterized FeIITPPSNO?. The pKa ...
Reactivity of iron(II)-bound nitrosyl hydride (HNO, nitroxyl) in aqueous solution
(Elsevier Science Inc, 2013-01)
The reactivity of coordinated nitroxyl (HNO) has been explored with the [FeII(CN)5HNO]3 - complex in aqueous medium, pH 6. We discuss essential biorelevant issues as the thermal and photochemical decompositions, the ...
Effect of nitroxyl on the hamster retinal nitridergic pathway
(Pergamon-Elsevier Science Ltd, 2007-11)
There is a growing body of evidence on the role of nitric oxide (NO) in retinal physiology. Recently, interest has developed in the functional role of an alternative redox form of NO, namely nitroxyl (HNO/NO), because it ...
Helpful correlations to estimate the pKaof coordinated HNO: a potential-pH exploration in a pendant-arm cyclam-based ruthenium nitroxyl
(Royal Society of Chemistry, 2021-01)
The acid-base speciation of coordinated azanone (HNO) remains a highly relevant topic in bioinorganic chemistry. Ruthenium nitroxyl complexes with sufficient robustness towards ligand loss have gained significance as ...
Coordinated nitroxyl anion is produced and released as nitrous oxide by the decomposition of iridium-coordinated nitrosothiols
(Elsevier Science Sa, 2011-01)
The aqueous decomposition of the iridium coordinated nitrosothiols (RSNOs) trans-K[IrCl4(CH3CN)NOSPh] (1), and K 2[IrCl5(NOECyS)] (2, ECyS = cysteine ethyl ester), was studied by MS analysis of the gaseous products, ESI-MS, ...
Rapid generation of HNO induced by visible light
(Royal Society of Chemistry, 2017-04)
We present a new method for controlled generation of HNO, based on the combination of a pH photoactuator induced by visible light with an HNO donor activated by pH increase. This method avoids the use of UV light, and in ...
Structure and reactivity of NO/NO+/NO− pincer and porphyrin complexes
(Wiley VCH Verlag, 2021-12)
This review covers recent progress in the field of nitrosyl pincer and porphyrinate complexes, and how their reactivity depends on the redox state of the NO ligand. Synthetic methods, and the most significant structural ...