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Coordinated nitroxyl anion is produced and released as nitrous oxide by the decomposition of iridium-coordinated nitrosothiols
(Elsevier Science SaLausanneSuíça, 2011)
The HNO donor ability of hydroxamic acids upon oxidation with cyanoferrates(III)
(Taylor & Francis Ltd, 2015-09)
The hydroxamic acids (RC(O)NHOH, HA) exhibit diverse biological activity, including hypotensive properties associated with formation of nitroxyl (HNO) or nitric oxide (NO). Oxidation of two HAs, benzohydroxamic and ...
Theoretical investigation of the mechanism of nitroxyl decomposition in aqueous solution
(Elsevier Science Inc, 2016-09)
Nitroxyl (HNO) is a species that has been proposed recently to play different roles in nitrosative stress processes. HNO decomposition in aqueous solution leading to N2O is a fast reaction that competes with many biochemical ...
Aorta from angiotensin II hypertensive mice exhibit preserved nitroxyl anion mediated relaxation responses
(ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTDLONDON, 2012)
Hypertension is a disorder affecting millions worldwide, and is a leading cause of death and debilitation in the United States. It is widely accepted that during hypertension and other cardiovascular diseases the vasculature ...
Nitrosyl-Centered Redox and Acid–Base Interconversions in [Ru(Me 3 [9]aneN 3 )(bpy)(NO)] 3,2,1+ . The p K a of HNO for its Nitroxyl Derivative in Aqueous Solution
(American Chemical Society, 2014-01)
This work reports the preparation of a new 6-coordinated nitrosyl compound and its use as a model to explore the redox and acid–base properties of the three redox states of bound nitrosyl (formally NO+, NO•, NO–/HNO) in ...
Nitric Oxide and Nitroxyl Products from the Reaction of L-Cysteine with trans-[RuNO(NH3)(4)P(OEt)(3)](PF6)(3)
(Wiley-Blackwell, 2015-02-01)
The reaction between the trans-[RuNO(NH3)(4)P(OEt)(3)](PF6)(3) and L-cysteine (RS-) was studied over a pH range of 2.0-7.4. In this reaction, the concentrations of NO and HNO produced varied as a function of the pH of the ...
Redox and antioxidant modulation of circadian rhythms : Effects of nitroxyl, N-acetylcysteine and glutathione
(Multidisciplinary Digital Publishing Institute, 2021)
Abstract: The circadian clock at the hypothalamic suprachiasmatic nucleus (SCN) entrains output
rhythms to 24-h light cycles. To entrain by phase-advances, light signaling at the end of subjective
night (circadian time ...
Antileishmanial activity of ruthenium(II)tetraammine nitrosyl complexes
(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2010)
The complexes trans-[Ru(NO)(NH(3))(4)L](X)(3) (X = BF(4)(-), PF(6)(-) or Cl(-) and L = N-heterocyclic ligands, P (OEt)(3), SO(3)(-2)), and [Ru(NO)Hedta)] were shown to exhibit IC(50pro) in the range of 36 (L = imN) to 5000 ...
Nitrite Reduction Mediated by Heme Models. Routes to NO and HNO?
(American Chemical Society, 2013-02-19)
The water-soluble ferriheme model Fe(III)(TPPS) mediates oxygen atom transfer from inorganic nitrite to a water-soluble phosphine (tppts), dimethyl sulfide, and the biological thiols cysteine (CysSH) and glutathione (GSH). ...
Reactions of HNO with Metal Porphyrins: Underscoring the Biological Relevance of HNO
(American Chemical Society, 2014-09)
Azanone (1 HNO, nitroxyl) shows interesting yet poorly understood chemical and biological effects. HNO has some overlapping properties with nitric oxide (NO), sharing its biological reactivity toward heme proteins, thiols, ...