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Impact of neurodegenerative diseases on human adult hippocampal neurogenesis
(American Association for the Advancement of Science, 2021-10-21)
Disrupted hippocampal performance underlies psychiatric comorbidities and cognitive impairments in patients with neurodegenerative disorders. To understand the contribution of adult hippocampal neurogenesis (AHN) to ...
Metacognition of emotion recognition across neurodegenerative diseases
(Elsevier Masson, 2021-04)
Metacognition (monitoring) of emotion recognition is fundamental for social interactions. Correct recognition of and confidence in the emotional meaning inferred from others' faces are fundamental for guiding and adjusting ...
PAMAM dendrimers as a carbamazepine delivery system for neurodegenerative diseases: A biophysical and nanotoxicological characterization
(Elsevier Science, 2018-06)
Carbamazepine (CBZ) is an antiepileptic drug, which also could be used in the treatment of neurodegenerative diseases, such as the Alzheimer's disease. However, its use has been limited due to its low solubility, inefficient ...
Regional brain susceptibility to neurodegeneration: What is the role of glial cells?
(Medknow Publications, 2020-05)
The main pathological feature of the neurodegenerative diseases is represented by neuronal death that represents the final step of a cascade of adverse/hostile events. Early in the neurodegenerative process, glial cells ...
Experimental Models of Neurodegenerative Diseases: A Simple Method to Check Both Viability of Neural Tissue and Cannulae Location After Stereotaxic Surgeries
(American Scientific Publishers, 2012-10)
The reagent MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a yellow tetrazole) is reduced to formazan in living cells, giving a purple colored product. The product absorbance issusceptible to be measured ...
Alteration of sphingolipids in biofluids: Implications for neurodegenerative Diseases
(Multidisciplinary Digital Publishing Institute, 2019-07-21)
Sphingolipids (SL) modulate several cellular processes including cell death, proliferation and autophagy. The conversion of sphingomyelin (SM) to ceramide and the balance between ceramide and sphingosine-1-phosphate (S1P), ...
Dancing with glia: The role of astrocytes, microglia and oligodendrocytes and their relation with neurons in neuroinflammation and aging
(Biomedscis, 2020-12-03)
This review provides an original overview of glial cells functions on the central nervous system and their relationship withneuroinflammation. We decided to correlate astrocytes, microglia and oligodendrocytes functions ...
Heme-Oxygenase-1
(Mary Ann Liebert, 2020-04-30)
This Forum issue “Heme Oxygenase” (HO) includes original research articles and reviews that are aimed at understanding the role of HO-1 in several pathophysiological conditions, specially addressing those involving ...
Effects of natural antioxidants in neurodegenerative disease
(Maney Publishing, 2012-01)
Polyphenols are secondary metabolites with antioxidant properties and are abundant in the diet. Fruits, vegetables, herbs, and various drinks (tea, wine, and juices) are all sources of these molecules. Despite their ...
Predicting and Characterizing Neurodegenerative Subtypes with Multimodal Neurocognitive Signatures of Social and Cognitive Processes
(IOS Press, 2021-08)
Background: Social cognition is critically compromised across neurodegenerative diseases, including the behavioral variant frontotemporal dementia (bvFTD), Alzheimer's disease (AD), and Parkinson's disease (PD). However, ...