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Unraveling the Burden of Iron in Neurodegeneration: Intersections with Amyloid Beta Peptide Pathology
(Hindawi Publishing Corporation, 2018-01-31)
Iron overload is a hallmark of many neurodegenerative processes such as Alzheimer's, Parkinson's, and Huntington's diseases. Unbound iron accumulated as a consequence of brain aging is highly reactive with water and oxygen ...
The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration
(Wiley, 2018-06)
Neurodegenerative disorders, such as Alzheimer´s, Parkinson´s, and prion diseases, are directly linked to the formation and accumulation of protein aggregates in the brain. These aggregates, principally made of proteins ...
Phospholipase D1 downregulation by α-synuclein: Implications for neurodegeneration in Parkinson's disease
(Elsevier, 2018-06-21)
We have previously shown that phospholipase D (PLD) pathways have a role in neuronal degeneration; in particular, we found that PLD activation is associated with synaptic injury induced by oxidative stress. In the present ...
Alteration of sphingolipids in biofluids: Implications for neurodegenerative Diseases
(Multidisciplinary Digital Publishing Institute, 2019-07-21)
Sphingolipids (SL) modulate several cellular processes including cell death, proliferation and autophagy. The conversion of sphingomyelin (SM) to ceramide and the balance between ceramide and sphingosine-1-phosphate (S1P), ...
COVID-19 in older people with cognitive impairment in Latin America
(Elsevier Science Inc., 2020-09)
The current COVID-19 pandemic provides a unique opportunity to investigate the hypothesis that viral infections can precipitate neurodegeneration. Severe acute respiratory syndrome coronavirus 1 (SARSCoV-1), a pathogenic ...
Editorial: Glial cells, maladaptive plasticity, and neurodegeneration: Mechanisms, targeted therapies, and future directions
(Frontiers Media S.A., 2021-04-30)
Understanding the biological complexity of the central nervous system (CNS) is a frontier in neuroscience. Morphological organization of the CNS represents the basis for its functional properties underlying higher brain ...
The delective glucocorticoid receptor modulator cort 113176 reduces neurodegeneration and neuroinflammation in Wobbler mice spinal cord
(Pergamon-Elsevier Science Ltd, 2018-08)
Wobbler mice are experimental models for amyotrophic lateral sclerosis. As such they show motoneuron degeneration, motor deficits, and astrogliosis and microgliosis of the spinal cord. Additionally, Wobbler mice show ...
Heparan sulphates, amyloidosis and neurodegeneration
(Viguera Editores, 2017-11)
Introducción. Numerosos trastornos neurodegenerativos se han asociado directamente a la acumulación de fibras amiloides. Estas fibras están formadas por proteínas o péptidos con conformaciones alteradas y que se agregan ...
Tetracycline repurposing in neurodegeneration: focus on Parkinson’s disease
(Springer Wien, 2018-08)
The prevalence of Parkinson´s disease, which affects millions of people worldwide, is increasing due to the aging population. In addition to the classic motor symptoms caused by the death of dopaminergic neurons, Parkinson´s ...
Colony-stimulating factor-1 receptor inhibition attenuates microgliosis and myelin loss but exacerbates neurodegeneration in the chronic cuprizone model
(Wiley Blackwell Publishing, Inc, 2021-12)
Multiple sclerosis (MS), especially in its progressive phase, involves early axonal and neuronal damage resulting from a combination of inflammatory mediators, demyelination, and loss of trophic support. During progressive ...