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Programmed hypertension in rats treated with a NF-kappa B inhibitor during nephrogenesis: renal mechanisms
(NATURE PUBLISHING GROUP, 2011)
Suppression of the renin-angiotensin system (RAS) during murine lactation causes progressive renal injury, indicating a physiological action of angiotensin II on nephrogenesis. The nuclear factor NF-kappa B system is one ...
Maternal undernutrition and the offspring kidney: from fetal to adult life
(Associação Brasileira de Divulgação Científica (ABRADIC), 2010-11-01)
Maternal dietary protein restriction during pregnancy is associated with low fetal birth weight and leads to renal morphological and physiological changes. Different mechanisms can contribute to this phenotype: exposure ...
Maternal undernutrition and the offspring kidney: from fetal to adult life
(Associação Brasileira de Divulgação Científica (ABRADIC), 2014)
Gestational Low Protein Diet Modulation on miRNA Transcriptome and Its Target During Fetal and Breastfeeding Nephrogenesis
(2021-06-22)
Background: The kidney ontogenesis is the most structurally affected by gestational protein restriction, reducing 28% of their functional units. The reduced nephron number is predictive of hypertension and cardiovascular ...
Alpha-tocopherol prevents intrauterine undernutrition-induced oligonephronia in rats
(SPRINGER, 2011)
The role of alpha-tocopherol during nephrogenesis was investigated in rats subjected to maternal undernutrition, which reduces the number of nephrons. alpha-tocopherol (350 mg/kg, p.o.) was administered daily to well-nourished ...
Maternal undernutrition and the offspring kidney: from fetal to adult life
(Associação Brasileira de Divulgação Científica (ABRADIC), 2010-11-01)
Maternal dietary protein restriction during pregnancy is associated with low fetal birth weight and leads to renal morphological and physiological changes. Different mechanisms can contribute to this phenotype: exposure ...
Maternal undernutrition and the offspring kidney: from fetal to adult life
(Associação Brasileira de Divulgação Científica, 2010)
AT(1) blockade during lactation as a model of chronic nephropathy: mechanisms of renal injury
(AMER PHYSIOLOGICAL SOC, 2008)
Suppression of the renin-angiotensin system during lactation causes irreversible renal structural changes. In this study we investigated 1) the time course and the mechanisms underlying the chronic kidney disease caused ...
Angiotensin I-converting enzyme isoforms (high and low molecular weight) in urine of premature and full-term infants
(Lippincott Williams & Wilkins, 2000-06-01)
Angiotensin I-converting enzyme (ACE) isoforms in urine from healthy and mildly hypertensive untreated patients have been described in the literature. Healthy subjects have high- and low-molecular-weight ACEs (170 and 65 ...
Changes in renal WT-1 expression preceding hypertension development
(BioMed Central, 2016-03)
Background: Hypertension is a public health problem with mostly unknown causes, and where strong hereditary genetic alterations have not been fully elucidated. However, the use of experimental models has provided valuable ...