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Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and enhances the efficacy of nifurtimox
(AMER SOC MICROBIOLOGY, 2008)
L-Buthionine (S,R)-sulfoximine (BSO) at a dose of 220 mg/kg of body weight/day showed an anti-Trypanosoma cruzi effect in infected mice, increasing their survival rate and decreasing the parasitemias and parasite burden ...
Role of the 207-218 peptide region of Moloney murine leukemia virus integrase in enzyme catalysis
(2010)
X-ray diffraction data on a few retroviral integrases show a flexible loop near the active site. By sequence alignment, the peptide region 207-218 of Mo-MLV IN appears to correspond to this flexible loop. In this study, ...
Amide-Linked C4″-saccharide modification of krn7000 provides potent stimulation of human invariant NKT cells and anti-tumor immunity in a humanized mouse model
(American Chemical Society, 2020)
Activation of invariant natural killer T (iNKT) cells
by α-galactosylceramides (α-GalCers) stimulates strong immune
responses and potent anti-tumor immunity. Numerous modifications
of the glycolipid structure have been ...
Antinociception induced by rosuvastatin in murine neuropathic pain
(Elsevier, 2018-06)
Background: Neuropathic pain, and subsequent hypernociception, can be induced in mice by paclitaxel (PTX) administration and partial sciatic nerve ligation (PSNL). Its pharmacotherapy has been a clinical challenge, due to ...
Dual and opposite roles of reactive oxygen species (ROS) in chagas disease: beneficial on the pathogen and harmful on the host
(Hindawi, 2020)
Chagas disease is a neglected tropical disease, which affects an estimate of 6-7 million people worldwide. Chagas disease is caused by Trypanosoma cruzi, which is a eukaryotic flagellate unicellular organism. At the primary ...
Interleukin-1beta in synergism gabapentin with tramadol in murine model of diabetic neuropathy
(Birkhauser Verlag AG, 2019)
Neuropathic pain is a complication of cancer and diabetes mellitus and the most commonly used drugs in the treatment of the diabetic neuropathic pain have only limited efficacy. The aim of this study was to evaluate the ...
A dorsal root ganglia cell line derived from trisomy 16 fetal mice, a model for Down syndrome
(Lippincott Williams and Wilkins, 2002)
We have established two immortalized cell lines from dorsal root ganglia of normal (G4b) and trisomy 16 mice (GTI), a model for Down syndrome. By immunohistochemistry, both cell lines exhibit neuronal traits and lack glial ...
Apoptosis is directly related to intracellular amyloid accumulation in a cell line derived from the cerebral cortex of a trisomy 16 mouse, an animal model of Down syndrome
(ELSEVIER, 2010)
Human Down syndrome (DS) represents the most frequent cause of mental retardation associated to
a genetic condition. DS also exhibits a characteristic early onset of neuropathology indistinguishable
from that observed ...
Targeting antisense mitochondrial ncRNAs inhibits murine melanoma tumor growth and metastasis through reduction in survival and invasion factors
(Impact Journals, 2016)
We reported that knockdown of the antisense noncoding mitochondrial RNAs (ASncmtRNAs) induces apoptotic death of several human tumor cell lines, but not normal cells, suggesting this approach for selective therapy against ...
Efficacy of quercetin against chemically induced murine oral squamous cell carcinoma
(Spandidos Publ, 2015)
Oral squamous cell carcinoma (OSCC) is the most common form of head and neck cancer, and oxidative damage is associated with the development of OSCCs. Antioxidants have therefore been proposed for use as chemoprotective ...