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Mostrando ítems 1-10 de 2090
Field effect in molecule-gated switches and the role of target-to-receptor size ratio in biosensor sensitivity
(2019-02-15)
We demonstrated here that molecular redox films are electrochemical capacitive devices possessing specific field effect in which molecular moieties within films act as sensitive gates. We confirm that the field effect ...
Beyond the Binding Site: In Vivo Identification of tbx2, smarca5 and wnt5b as Molecular Targets of CNBP during Embryonic Development.
(Public Library Science, 2013-05)
CNBP is a nucleic acid chaperone implicated in vertebrate craniofacial development, as well as in myotonic dystrophy type 2 (DM2) and sporadic inclusion body myositis (sIBM) human muscle diseases. CNBP is highly conserved ...
Repression: Targeting the heart of the matter
(Cell Press, 1999)
Molecular epidemiology: The impact of molecular biology in epidemiology research
(Sociedad Médica de Santiago, 2000)
Synergizing immunotherapy with molecularly targeted anticancer treatment
(Elsevier, 2014-09)
The therapeutic opportunity for anticancer kinase inhibitors (KIs) that block cell-signaling pathways is materializing. Yet, these molecular-targeted therapies are not tailored to be allies of the immune system, and often ...
Translation controlled mRNAs: New drug targets in infectious diseases?
(Bentham Science Publishers B.V., 2009)
Recent data from a series of laboratories has pinpointed the relevant role of translation control on the regulation of gene expression. In particular, an analysis of T cell activation has led to demonstrate that during ...
Identification of potential therapeutic targets in prostate cancer through a cross-species approach
(2018-03-01)
Genetically engineered mouse models of cancer can be used to filter genome-wide expression datasets generated from human tumours and to identify gene expression alterations that are functionally important to cancer development ...
Conservation of dual-targeted proteins in Arabidopsis and rice points to a similar pattern of gene-family evolution
(SPRINGER HEIDELBERG, 2009)
Gene duplication followed by acquisition of specific targeting information and dual targeting were evolutionary strategies enabling organelles to cope with overlapping functions. We examined the evolutionary trend of ...