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microRNA Expression Profiling in Young Prostate Cancer Patients
MicroRNAs (miRNAs) are small, non-coding RNA molecules with multiple roles in many biological processes. Few studies have shown the molecular characteristics in younger prostate cancer (PCa) patients. In this study, we ...
Análise do perfil de miRNAs envolvidos na resistência à morte celular em células de leucemia linfocítica crônica in vitro (MEC-1)
(Universidade Federal de São Paulo (UNIFESP), 2021)
This study aims to evaluate the profile of miRNAs in CLL lineage, to find changes related to greater survival rate of these cells. The strategy was the comparison of the miRNA profile expressed by B-1 cells from healthy ...
GH Overexpression Alters Spermatic Cells MicroRNAome Profile in Transgenic Zebrafish
(2021-09-08)
Overexpression of growth hormone (GH) in gh-transgenic zebrafish of a highly studied lineage F0104 has earlier been reported to cause increased muscle growth. In addition to this, GH affects a broad range of cellular ...
Integrative transcriptome analysis identifies deregulated microRNA-transcription factor networks in lung adenocarcinoma
(2016-05-17)
Herein, we aimed at identifying global transcriptome microRNA (miRNA) changes and miRNA target genes in lung adenocarcinoma. Samples were selected as training (N = 24) and independent validation (N = 34) sets. Tissues were ...
Association of single nucleotide polymorphisms in Pre-miR-27a, Pre-miR-196a2, Pre-miR-423, miR-608 and Pre-miR-618 with breast cancer susceptibility in a South American population
(2016)
Background: MicroRNAs (miRNAs) are a novel class of endogenous, non-coding, single-stranded RNAs capable of regulating gene expression by suppressing translation or degrading mRNAs. Single nucleotide polymorphisms (SNP) ...
MiR-125a-3p and miR-320b differentially expressed in patients with chronic myeloid leukemia treated with allogeneic hematopoietic stem cell transplantation and imatinib mesylate
(2021-10-01)
Chronic myeloid leukemia (CML), a hematopoietic neoplasm arising from the fusion of BCR (breakpoint cluster region) gene on chromosome 22 to the ABL (Abelson leukemia virus) gene on chromosome 9 (BCR-ABL1 oncogene), ...
Integration of miRNA and mRNA expression profiles reveals microRNA-regulated networks during muscle wasting in cardiac cachexia
(2017-12-01)
Cardiac cachexia (CC) is a common complication of heart failure (HF) associated with muscle wasting and poor patient prognosis. Although different mechanisms have been proposed to explain muscle wasting during CC, its ...
Análise da expressão de miR-21-5p e miR-105-5p no soro de pacientes com câncer gástrico
(Universidade Federal de São Paulo, 2022-09-12)
O câncer gástrico (CG) é uma das mais frequentes e letais neoplasias do mundo.
Contudo, ainda existem poucas ferramentas eficazes para seu diagnóstico,
monitoramento e resposta ao tratamento. Estudos sobre biomarcadores ...
Association of single nucleotide polymorphisms in Pre-miR-27a, Pre-miR-196a2, Pre-miR-423, miR-608 and Pre-miR-618 with breast cancer susceptibility in a South American population
(BioMed Central Ltd., 2016)
© 2016 The Author(s).Background: MicroRNAs (miRNAs) are a novel class of endogenous, non-coding, single-stranded RNAs capable of regulating gene expression by suppressing translation or degrading mRNAs. Single nucleotide ...