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Cardiorespiratory and neuroendocrine changes induced by methadone in conscious and in isoflurane anaesthetised dogs
(Elsevier B.V., 2012-12-01)
The aim of this study was to compare the cardiorespiratory and neurohormonal effects of methadone in conscious and in isoflurane anaesthetised dogs. Six mature dogs (28.0 +/- 3.8 kg bodyweight) received intravenous (IV) ...
Effects of methadone, alone or in combination with acepromazine or xylazine, on sedation and physiologic values in dogs
(Wiley-Blackwell, 2008-11-01)
Objective To evaluate the effects of methadone, administered alone or in combination with acepromazine or xylazine, on sedation and on physiologic values in dogs.Study design Randomized cross-over design.Animals Six adult ...
Determination of the sevoflurane sparing effect of methadone in cats
(Wiley-Blackwell, 2011-07-01)
Objective To determine the magnitude and duration of sevoflurane minimum alveolar concentration (MAC) reduction following a single intravenous (IV) dose of methadone in cats.Study design Prospective experimental study.Animals ...
Determination of the sevoflurane sparing effect of methadone in cats
(Wiley-Blackwell, 2014)
Plasma concentrations and behavioral, antinociceptive, and physiologic effects of methadone after intravenous and oral transmucosal administration in cats
(Amer Veterinary Medical Assoc, 2011-06-01)
Objective-To determine plasma concentrations and behavioral, antinociceptive, and physiologic effects of methadone administered via IV and oral transmucosal (OTM) routes in cats.Animals-8 healthy adult cats.Procedures-Methadone ...
Pharmacokinetics and pharmacodynamics of the injectable formulation of methadone hydrochloride and methadone in lipid nanocarriers administered orally to horses
(2017-08-01)
We investigated the thermal, electrical and mechanical antinociceptive and physiological effects (heart rate, respiratory rate, arterial blood pressure, head height and abdominal auscultation score), and pharmacokinetics, ...
Comparison of the effects of epidural or intravenous methadone on the minimum alveolar concentration of isoflurane in dogs
(Elsevier B.V., 2012-06-01)
The effects of epidural and intravenous (IV) methadone (0.5 mg/kg) on the minimum alveolar concentration of isoflurane (ISOMAC) were compared in dogs. Six dogs (16.5 +/- 2.5 kg bodyweight) received three treatments in ...
Effects of methadone on the minimum alveolar concentration of isoflurane in dogs
(Wiley-Blackwell, 2010-05-01)
Objective To investigate the effects of methadone on the minimum alveolar concentration of isoflurane (ISO(MAC)) in dogs.Study design Prospective, randomized cross-over experimental study.Animals Six adult mongrel dogs, ...