Now showing items 1-10 of 366
Development and evaluation of an emulsion containing lycopene for combating acceleration of skin aging
Lycopene, a carotenoid and potent antioxidant is found in large quantities in tomatoes. Lycopene combats diseases, such as cardiovascular disease and different types of cancer, including prostate cancer. However, its topical ...
Effect of lycopene on doxorubicin-induced cardiotoxicity: An echocardiographic, histological and morphometrical assessment
(Blackwell Publishing, 2007-07-01)
Doxorubicin is an excellent chemotherapeutic agent utilized for several types of cancer but the irreversible doxorubicin-induced cardiac damage is the major limitation for its use. Oxidative stress seems to be associated ...
Doxorubicin as an antioxidant: Maintenance of myocardial levels of lycopene under doxorubicin treatment
(Elsevier B.V., 2007-09-01)
The mechanism of doxorubicin-induced cardiotoxicity remains controversial. Wistar rats (n=96) were randomly assigned to a control (C), lycopene (L), doxorubicin (D), or doxorubicin+lycopene (DL) group. The L and DL groups ...
Lycopene Epoxides and Apo-Lycopenals Formed by Chemical Reactions and Autoxidation in Model Systems and Processed Foods
Bioavailability of synthetic and biosynthetic deuterated lycopene in humans
(Elsevier B.V., 2005-04-01)
Current knowledge of the bioavailability of lycopene in humans is limited due to the inability to distinguish newly administered lycopene from the body reserves of lycopene. A quantitative method to assess the absorption ...
Lycopene supplementation modulates plasma concentrations and epididymal adipose tissue mRNA of leptin, resistin and IL-6 in diet-induced obese rats
(Cambridge University Press, 2013-11-28)
Obesity is characterised by chronic low-grade inflammation, and lycopene has been reported to display anti-inflammatory effects. However, it is not clear whether lycopene supplementation modulates adipokine levels in vivo ...
Comparative effects of acute and subacute lycopene administration on chromosomal aberrations induced by cisplatin in male rats
(Elsevier B.V., 2006-08-01)
Lycopene is a natural carotenoid, free radical scavenger, and presents protective effects by inhibiting oxidative DNA damage. The objective of the current study was to investigate the cytogenetic effects of a single acute ...
Antigenotoxicity and antimutagenicity of lycopene in HepG2 cell line evaluated by the comet assay and micronucleus test
(Pergamon-Elsevier B.V. Ltd, 2008-03-01)
Epidemiological studies have provided evidence that high consumption of tomatoes effectively reduces the risk of reactive oxygen species (ROS)-mediated diseases such as cancer. Tomatoes are rich sources of lycopene, a ...
Lycopene activity against chemically induced DNA damage in Chinese hamster ovary cells
(Elsevier B.V., 2007-08-01)
Lycopene is a natural pigment synthesized by plants and microorganisms, and it is mainly found in tomatoes. It is an acyclic isomer of P-carotene and one of the most potent antioxidants. Several studies have demonstrated ...