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Leptin resensitisation: A reversion of leptin-resistant states
(BioScientifica, 2019-06)
Leptin resistance refers to states in which leptin fails to promote its anticipated effects, frequently coexisting with hyperleptinaemia. Leptin resistance is closely associated with obesity and also observed in physiological ...
Increased leptin storage with altered leptin secretion from adipocytes of rats with sucrose-induced dyslipidemia and insulin resistance: effect of dietary fish oil
(W B Saunders Co-Elsevier Inc, 2010-06)
This study examined the effect of long-term feeding a high-sucrose diet (SRD) on the modulation of rat adipocyte's leptin secretion and storage. For this purpose, we analyzed (a) basal and insulin-stimulated leptin release ...
Insulin enhances leptin expression in human trophoblastic cells
(Oxford University Press, 2013-06)
Leptin, one of the adipokines that controls energy metabolism via the central nervous system, also has pleiotropic peripheral effects, acting as a proinflammatory cytokine. Leptin is also produced by trophoblastic cells ...
Sam68 mediates leptin-stimulated growth by modulating leptin receptor signaling in human trophoblastic JEG-3 cells
(Oxford University Press, 2011-06)
Background Sam68, a member of the signal transduction and activation of RNA metabolism (STAR) family of RNA-binding proteins, has been previously implicated as an adaptor molecule in different signaling systems, including ...
Leptin stimulates protein synthesis-activating translation machinery in human trophoblastic cells
(Society for the Study of Reproduction, 2009-06)
Leptin was originally considered as an adipocyte-derived signaling molecule for the central control of metabolism. However, pleiotropic effects of leptin have been identified in reproduction and pregnancy, particularly in ...
Involvement of leptin in the molecular physiology of the placenta
(BioScientifica, 2018-01)
Leptin is a homeostatic regulator in the placenta where it promotes proliferation, protein synthesis and the expression of tolerogenic maternal response molecules such as HLA-G. Leptin also exerts an anti-apoptotic action ...
Leptin receptor activation increases Sam68 tyrosine phosphorylation and expression in human trophoblastic cells
(Elsevier Ireland, 2011-01)
Leptin is produced in placenta where it has been found to be an important autocrine signal for trophoblastic growth during pregnancy, promoting antiapoptotic and trophic effects. Leptin receptor is present in trophoblastic ...
Leptin promotes cell proliferation and survival of trophoblastic cells
(Society for the Study of Reproduction, 2007-02)
Leptin, the 16-kDa protein product of the obese gene, was originally considered as an adipocyte-derived signaling molecule for the central control of metabolism. However, leptin has been suggested to be involved in other ...
Effects of leptin on pedunculopontine nucleus (PPN) neurons
(Springer Wien, 2013-07)
Leptin, a hormone that regulates appetite and energy expenditure, is increased in obese individuals, although these individuals often exhibit leptin resistance. Obesity is characterized by sleep/wake disturbances, such as ...
Regulation of leptin expression by 17beta-estradiol in human placental cells involves membrane associated estrogen receptor alpha.
(Elsevier, 2012-01)
The placenta produces a wide number of molecules that play essential roles in the establishment and maintenance of pregnancy. In this context, leptin has emerged as an important player in reproduction. The synthesis of ...