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Role of MMP9 on Invadopodia Formation in Cells From Adenoid Cystic Carcinoma. Study by Laser Scanning Confocal Microscopy
(WILEY-LISS, 2010)
Migration, invasion and protease activity are essential for tumor progression and metastasis. Metastatic cells rely on invadopodia to degrade and invade extracellular matrix (ECM). Invadopodia are membrane protrusions with ...
Cellular and Molecular Mechanisms of MT1-MMP-Dependent Cancer Cell Invasion
(Annual Reviews, 2016-10)
Metastasis is responsible for most of cancer-associated deaths. Accumulating evidence based on 3D migration models has revealed a diversity of invasive migratory schemes reflecting the plasticity of tumor cells to switch ...
PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K
(2017-11-02)
The PI3K signaling pathway regulates cell growth and movement and is heavily mutated in cancer. Class I PI3Ks synthesize the lipid messenger PI(3,4,5)P3. PI(3,4,5)P3 can be dephosphorylated by 3- or 5-phosphatases, the ...
Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function
(Nature Publishing Group, 2018-07)
Membrane type 1-matrix metalloproteinase (MT1-MMP), a membrane-tethered protease, is key for matrix breakdown during cancer invasion and metastasis. Assembly of branched actin networks by the Arp2/3 complex is required for ...
Identification of a CIP4 PKA phosphorylation site involved in the regulation of cancer cell invasiveness and metastasis
(Elsevier Ireland, 2019-10)
CDC42 interacting protein 4 (CIP4) is a CDC42 effector that coordinates membrane deformation and actin polymerization. The correlation of CIP4 overexpression with metastatic capacity has been characterized in several types ...
Decreased expression of ADAMTS-1 in human breast tumors stimulates migration and invasion
(2013)
Abstract
Background
ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin motifs) is a member of the ADAMTS family ...
Decreased expression of ADAMTS-1 in human breast tumors stimulates migration and invasion
(2013-01-05)
Abstract
Background
ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin motifs) is a member of the ADAMTS family of metalloproteases. Here, we investigated mRNA ...
Decreased expression of ADAMTS-1 in human breast tumors stimulates migration and invasion
(2013-01-05)
Abstract
Background
ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin motifs) is a member of the ADAMTS family of metalloproteases. Here, we investigated mRNA ...
Formação de invadopódios na migração de células neoplásicas malignas expostas à fibronectina
(Universidade Estadual Paulista (Unesp), 2018-02-28)
Durante processos patológicos como o câncer, a atividade migratória de células neoplásicas aumenta, sendo um passo crítico para a disseminação dessas células a órgãos distantes. O processo migratório dessas células depende ...
Enterolobium contortisiliquum Trypsin Inhibitor (EcTI), a Plant Proteinase Inhibitor, Decreases in Vitro Cell Adhesion and Invasion by Inhibition of Src Protein-Focal Adhesion Kinase (FAK) Signaling Pathways
(Amer Soc Biochemistry Molecular Biology Inc, 2012-01-02)
Tumor cell invasion is vital for cancer progression and metastasis. Adhesion, migration, and degradation of the extracellular matrix are important events involved in the establishment of cancer cells at a new site, and ...