Now showing items 1-10 of 113
Insulin therapy and fetoplacental vascular function in gestational diabetes mellitus
What is the topic of this review? This review focuses on the effects of insulin therapy on fetoplacental vasculature in gestational diabetes mellitus and the potentiating effects of adenosine on this therapy. What advances ...
Insulin/adenosine axis linked signalling
Regulation of blood flow depends on systemic and local release of vasoactive molecules such as insulin and adenosine. These molecules cause vasodilation by activation of plasma membrane receptors at the vascular endothelium. ...
Insulin receptor isoforms: an integrated view focused on gestational diabetes mellitus
The human insulin receptor (IR) exists in two isoforms that differ by the absence (IR-A) or the presence (IR-B) of a 12-amino acid segment encoded by exon 11. Both isoforms are functionally distinct regarding their binding ...
Role of insulin, adenosine, and adipokine receptors in the foetoplacental vascular dysfunction in gestational diabetes mellitus
Gestational diabetes mellitus (GDM) is a disease of pregnancy associated with maternal and foetal hyperglycaemia and altered foetoplacental vascular function. Human foetoplacental microvascular and macrovascular endothelium ...
Modulation of insulin-like receptor gene (MdIR) in response to feeding in the surf clam Mesodesma donacium (Lamarck, 1818)
The objective was to evaluate the modulation of gene expression of insulin-like receptor (a receptor with a fundamental role in insulin-signalling pathway) in response to feeding in the bivalve Mesodesma donacium. A partial ...
Pro-angiogenic role of insulin: from physiology to pathology
The underlying molecular mechanisms involve in the regulation of the angiogenic process by insulin are not well understood. In this review article, we aim to describe the role of insulin and insulin receptor activation on ...