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Glucose-induced insulin secretion is impaired and insulin-induced phosphorylation of the insulin receptor and insulin receptor substrate-1 are increased in protein-deficient rats
(1997-03-01)
Malnutrition is related to diabetes in tropical countries. In experimental animals, protein deficiency may affect insulin secretion. However, the effect of malnutrition on insulin receptor phosphorylation and further ...
Protein deficiency and nutritional recovery modulate insulin secretion and the early steps of insulin action in rats
(1998-10-01)
Maternal malnutrition was shown to affect early growth and leads to permanent alterations in insulin secretion and sensitivity of offspring. In addition, epidemiological studies showed an association between low birth ...
Protein deficiency and nutritional recovery modulate insulin secretion and the early steps of insulin action in rats
(1998-10-01)
Maternal malnutrition was shown to affect early growth and leads to permanent alterations in insulin secretion and sensitivity of offspring. In addition, epidemiological studies showed an association between low birth ...
Pancreatic β-cell defects in women at risk of type 2 diabetes
(2004-02-01)
We evaluated insulin release and insulin sensitivity in women with basal and/or postprandial hyperglycemia but normal oral glucose tolerance test (OGTT) in previous pregnancy (GHG). These women were individually matched ...
Pancreatic β-cell defects in women at risk of type 2 diabetes
(2004-02-01)
We evaluated insulin release and insulin sensitivity in women with basal and/or postprandial hyperglycemia but normal oral glucose tolerance test (OGTT) in previous pregnancy (GHG). These women were individually matched ...
Subclinical abnormalities of glucose metabolism in Brazilian women with a history of gestational diabetes mellitus
(Blackwell Munksgaard, 2004-12-01)
Background. To evaluate insulin release and insulin sensitivity in women with prior gestational diabetes mellitus (GDM) to gain a better understanding of type 2 diabetes pathogenesis.Methods. GDM women were individually ...
Subclinical abnormalities of glucose metabolism in Brazilian women with a history of gestational diabetes mellitus
(Blackwell Munksgaard, 2004-12-01)
Background. To evaluate insulin release and insulin sensitivity in women with prior gestational diabetes mellitus (GDM) to gain a better understanding of type 2 diabetes pathogenesis.Methods. GDM women were individually ...
PLGA based drug delivery systems (DDS) for the sustained release of insulin: Insight into the protein/polyester interactions and the insulin release behavior
(John Wiley & Sons Ltd, 2010-12)
BACKGROUND: Drug delivery systems (DDS) were designed using insulin as model drug and poly (lactic-co-glycolic) copolymers (PLGA) as polymeric matrix. The carriers were synthesized by direct self-assembly of the insulin ...
Insulin-loaded liposomes functionalized with cell-penetrating peptides: influence on drug release and permeation through porcine nasal mucosa
(2021-08-05)
The nasal route is promising for the delivery of insulin for diabetes treatment. Drug loading into delivery systems such as liposomes can improve the bioavailability of insulin for this route. Herein, we address the ...