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The zebrafish perivitelline fluid provides maternally-inherited defensive immunity
(MDPI, 2020)
In the teleost egg, the embryo is immersed in an extraembryonic fluid that fills the space between the embryo and the chorion and partially isolates it from the external environment, called the perivitelline fluid (PVF). ...
Stage-specific role of interferon-gamma in experimental autoimmune encephalomyelitis and multiple sclerosis
(Frontiers Media, 2015)
The role of interferon (IFN)-gamma in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), has remained as an enigmatic paradox for more than 30 years. Several studies attribute ...
The damage signals hypothesis of Alzheimer's disease pathogenesis
(IOS Press, 2008)
Virtually none of the hypotheses on Alzheimer's disease (AD) pathogenesis address the earliest events that trigger the molecular alterations that precede cerebral degeneration and account for the diversity of risk factors ...
Desired immune response characteristics in an RSV vaccine: What infants tell us
(Elsevier, 2009)
Respiratory syncytial virus (RSV) represents an important target for vaccine development. The design of an
effective vaccine for infants is hindered by a lack of knowledge of the nature of the protective immune response ...
IL-33 Alarmin and its active proinflammatory fragments are released in small intestine in celiac disease
(Frontiers Media, 2020)
Initially described as Th2 promoter cytokine, more recently, IL-33 has been recognized as an alarmin, mainly in epithelial and endothelial cells. While localized in the nucleus acting as a gene regulator, it can be also ...
Viral recognition by the innate immune system : the role of pattern recognition receptors.
(2011-11-11)
Pattern recognition receptors are the main sensors of the innate immune response. Their function is to recognize pathogenassociated
molecular patterns, which are molecules essential for the survival of microbial pathogens, ...
Sublethal doses of dinophysistoxin-1 and okadaic acid stimulate secretion of inflammatory factors on innate immune cells: Negative health consequences
(Elsevier Ltd, 2017)
© 2016 Elsevier LtdOne of the proposed mechanisms to explain why Diarrhetic Shellfish Poison (DSP) toxins are tumor promoters is founded on the capacity of these toxins to increase TNF-α secretion. Although macrophages are ...
Crosstalk between body microbiota and the regulation of immunity
(Hindawi, 2022)
The microbiome corresponds to the genetic component of microorganisms (archaea, bacteria, phages, viruses, fungi, and protozoa) that coexist with an individual. During the last two decades, research on this topic has become ...
Determinants of Periodontal/Periapical Lesion Stability and Progression
(SAGE, 2020)
Periodontal and periapical lesions are infectious inflammatory osteolitytic conditions in which a complex inflammatory immune response mediates bone destruction. However, the uncertainty of a lesion's progressive or stable ...
Innate immunity restoration in patients with HIV/AIDS infection associated with antiretroviral therapy Restauración de la inmunidad innata en pacientes con infección por VIH/SIDA después de inicio de terapia antirretroviral
(2006)
Background: Highly active antiretroviral therapy (HAART) in HIV/AIDS infection induces an important reduction of the viral load (VL) and an immune system reconstitution. CD4+ T lymphocyte count is the immunological measurement ...