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Antidepressant imipramine diminishes stress-induced inflammation in the periphery and central nervous system and related anxiety- and depressive- like behaviors
(2016)
In order to relieve anxiety and depression accompanying stress, physicians resort to tricyclic antidepressants, such as imipramine. We had previously shown that imipramine reversed stress-induced social avoidance behavior, ...
Antimalarial effect in vitro and lack of modulating effect of desipramine and imipramine
(Royal Soc Tropical Medicine, 1997-11-01)
Based on previous studies in vitro of the modulating effect of desipramine on chloroquine-resistance of Plasmodium falciparum, the effect of desipramine and imipramine on freshly isolated resistant Brazilian strains of the ...
Antimalarial effect in vitro and lack of modulating effect of desipramine and imipramine
(Royal Soc Tropical Medicine, 1997-11-01)
Based on previous studies in vitro of the modulating effect of desipramine on chloroquine-resistance of Plasmodium falciparum, the effect of desipramine and imipramine on freshly isolated resistant Brazilian strains of the ...
Harmine and imipramine promote antioxidant activities in prefrontal cortex and hippocampus
(LANDES BIOSCIENCE, 2010)
A growing body of evidence has suggested that reactive oxygen species (ROS) may play an important role in the physiopathology of depression. Evidence has pointed to the beta-carboline harmine as a potential therapeutic ...
Chronic imipramine treatment-induced changes in acetylcholinesterase (EC 3.1.1.7) activity in discrete rat brain regions
(Associação Brasileira de Divulgação Científica, 1997-08-01)
Cholinergic as well as monoaminergic neurotransmission seems to be involved in the etiology of affective disorders. Chronic treatment with imipramine, a classical antidepressant drug, induces adaptive changes in monoaminergic ...
Involvement of alpha(1B)-adrenoceptors in the anti-immobility effect of imipramine in the tail suspension test
(Elsevier B.V., 2015-03-05)
Imipramine is a tricyclic antidepressant inhibitor of norepinephrine and serotonin neuronal reuptake. The roles of specific alpha(1)-adrenoceptor subtypes that might be targeted by the increased synaptic levels of noradrenaline ...
Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance
(2015-05)
Psychosocial stress is associated with altered immunity, anxiety and depression. Previously we showed
that repeated social defeat (RSD) promoted microglia activation and social avoidance behavior that persisted
for 24 ...
Imipramine enhances cell proliferation and decreases neurodegeneration in the hippocampus after transient global cerebral ischemia in rats
(ELSEVIER IRELAND LTD, 2010)
This study was aimed to determine whether imipramine chronic treatment promotes neurogenesis in the dentate gyrus (DG) and interferes with neuronal death in the CA1 subfield of the hippocampus after transient global cerebral ...