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Clinical and Molecular Features of Late Onset Huntington Disease in a Peruvian Cohort
(IOS Press, 2015)
Background: Late onset cases of Huntington disease (HD), with onset ≥60 years, account for up to 20% of HD cases worldwide. Clinical features include mild motor dysfunction with slow progression and cognitive impairment, ...
Structural neuroimaging differentiates vulnerability from disease manifestation in colombian families with Huntington's disease
(John Wiley & Sons Inc, 2019-07)
Introduction: The volume of the striatal structures has been associated with disease progression in individuals with Huntington's disease (HD) from North America, Europe, and Australia. However, it is not known whether the ...
Losing ground: Frontostriatal atrophy disrupts language embodiment in Parkinson's and Huntington's disease
(Pergamon-Elsevier Science Ltd, 2017-09)
Within the language domain, movement disorders triggered by frontostriatal damage are characterized by deficits in action verbs, motor-language coupling, and syntax. However, these impairments have not been jointly interpreted ...
Action-semantic and syntactic deficits in subjects at risk for Huntington's disease
(British Psychological Soc, 2017-02)
Frontostriatal networks play critical roles in grounding action semantics and syntactic skills. Indeed, their atrophy distinctively disrupts both domains, as observed in patients with Huntington's disease (HD) and Parkinson's ...
Neuroinflammation in Huntington’s Disease: A Starring Role for Astro-cyte and Microglia
(Bentham Science Publishers, 2021-11-26)
Huntington’s disease (HD) is a neurodegenerative genetic disorder caused by a CAG repeat expansion in the huntingtin gene. HD causes motor, cognitive, and behavioral dysfunction. Since no existing treatment affects the ...
Clinical and genetic characteristics in patients with Huntington's Disease from Argentina
(Elsevier, 2012-02)
Huntington's Disease (HD) is a neurodegenerative disease, caused by the expansion of an unstable (CAG) n in the HTT gene. There is scarce data about the disease in Argentina. Objective: To describe the demographic, clinical ...
A Comprehensive Haplotype Targeting Strategy for Allele-Specific HTT Suppression in Huntington Disease.
(Elsevier, 2019)
Huntington disease (HD) is a fatal neurodegenerative disorder caused by a gain-of-function mutation in HTT. Suppression of mutant HTT has emerged as a leading therapeutic strategy for HD, with allele-selective approaches ...
Your misery is no longer my pleasure: Reduced schadenfreude in Huntington's disease families
(Elsevier Masson, 2016-10)
Schadenfreude – pleasure at others' misfortunes – has been systematically related to ventral striatum activity. This brain region is affected early in individuals with manifest and pre-manifest Huntington's disease (HD). ...
Efector del factor de crecimiento nervioso (NGF) sobre la conducta en un modelo experimental de Corea de Huntington en ratas.
(Ibagu? : Universidad del Tolima, 2006.170 COL CO, 2014)