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Reliable identification of mycobacterial species by PCR-restriction enzyme analysis (PRA)-hsp65 in a reference laboratory and elaboration of a sequence-based extended algorithm of PRA-hsp65 patterns
(2008)
Abstract
Background
Identification of nontuberculous mycobacteria (NTM) based on phenotypic tests is time-consuming, ...
Autolytic Mycobacterium leprae Hsp65 fragments may act as biological markers for autoimmune diseases
(ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2011)
Investigating the proteolytic activity of the recombinant Mycobacterium leprae Heat Shock Protein of 65 kDa (rHsp65), chaperonin 2 (cpn2), we observed that it displays high instability. The fragmentation process starts at ...
Th1 polarized response induced by intramuscular DNA-HSP65 immunization is preserved in experimental atherosclerosis
(Associação Brasileira de Divulgação Científica (ABRADIC), 2007-11-01)
We previously reported that a DNA vaccine constructed with the heat shock protein (HSP65) gene from Mycobacterium leprae (DNA-HSP65) was protective and also therapeutic in experimental tuberculosis. By the intramuscular ...
Th1 polarized response induced by intramuscular DNA-HSP65 immunization is preserved in experimental atherosclerosis
(Associação Brasileira de Divulgação Científica (ABRADIC), 2007-11-01)
We previously reported that a DNA vaccine constructed with the heat shock protein (HSP65) gene from Mycobacterium leprae (DNA-HSP65) was protective and also therapeutic in experimental tuberculosis. By the intramuscular ...
Immune regulatory effect of pHSP65 DNA therapy in pulmonary tuberculosis: activation of CD8(+) cells, interferon-gamma recovery and reduction of lung injury
(Blackwell Publishing, 2004-09-01)
A DNA vaccine based on the heat-shock protein 65 Mycobacterium leprae gene (pHSP65) presented a prophylactic and therapeutic effect in an experimental model of tuberculosis. In this paper, we addressed the question of which ...
Immunomodulation and protection induced by DNA-hsp65 vaccination in an animal model of arthritis
(Mary Ann Liebert, Inc., 2005-11-01)
We described a prophylactic and therapeutic effect of a DNA vaccine encoding the Mycobacterium leprae 65- kDa heat shock protein (DNA-hsp65) in experimental murine tuberculosis. However, high homology of the vaccine to the ...
Immunomodulation and protection induced by DNA-hsp65 vaccination in an animal model of arthritis
(Mary Ann Liebert, Inc., 2005-11-01)
We described a prophylactic and therapeutic effect of a DNA vaccine encoding the Mycobacterium leprae 65- kDa heat shock protein (DNA-hsp65) in experimental murine tuberculosis. However, high homology of the vaccine to the ...
Th1 polarized response induced by intramuscular DNA-HSP65 immunization is preserved in experimental atherosclerosis
(Associação Brasileira de Divulgação Científica (ABRADIC), 2014)
Mycobacterium leprae Hsp65 administration reduces the lifespan of aged high antibody producer mice
(2014-03-26)
Abstract
Background
Aging process may result in immune modifications that lead to disruption of innate and acquired immunity mechanisms that may induce chronic-degenerative ...