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The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration
(Wiley, 2018-06)
Neurodegenerative disorders, such as Alzheimer´s, Parkinson´s, and prion diseases, are directly linked to the formation and accumulation of protein aggregates in the brain. These aggregates, principally made of proteins ...
Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia
(Frontiers Research FoundationGrupo ReproducciónSuiza, 2020)
Interference in dengue virus adsorption and uncoating by carrageenans
(Academic Press Inc Elsevier Science, 2007-07)
This study demonstrated that the λ- and ι-carrageenans, sulfated polysaccharides containing linear chains of galactopyranosyl residues, are potent inhibitors of dengue virus type 2 (DENV-2) and 3 (DENV-3) multiplication ...
Heparin enhances protamine disulfide bond reduction during in vitro decondensation of human spermatozoa
(Oxford University Press, 2012-05-02)
BACKGROUND: Human sperm nuclear decondensation in vivo involves protamine disulfide bond reduction by glutathione (GSH) and protamine/histone exchange, presumably with heparan sulfate (HS) as the protamine acceptor. The ...
Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance
(Wiley Blackwell Publishing, Inc, 2019-06-23)
In contrast to the bulk of the tumor, a subset of cancer cells called cancer stem cells (or tumor-initiating cells) is characterized by self-renewal, unlimited proliferative potential, expression of multidrug-resistance ...
Sulfated xylomannans from the red seaweed Sebdenia polydactyla: Structural features, chemical modification and antiviral activity
(International Medical Press, 2009-04)
Background: Many viruses display affinity for cell surface heparan sulfate proteoglycans with biological relevance in virus entry. This raises the possibility of the application of sulfated polysaccharides in antiviral ...