Search
Now showing items 1-10 of 2191
An ensemble framework for identifying essential proteins
(2016-08-25)
Background: Many centrality measures have been proposed to mine and characterize the correlations between network topological properties and protein essentiality. However, most of them show limited prediction accuracy, and ...
Predicting Essential Genes and Proteins Based on Machine Learning and Network Topological Features: A Comprehensive Review
(Frontiers Media Sa, 2016-03-08)
Essential proteins/genes are indispensable to the survival or reproduction of an organism, and the deletion of such essential proteins will result in lethality or infertility. The identification of essential genes is very ...
In silico network topology-based prediction of gene essentiality
(Elsevier B.V., 2008-02-01)
The identification of genes essential for survival is important for the understanding of the minimal requirements for cellular life and for drug design. As experimental studies with the purpose of building a catalog of ...
In silico network topology-based prediction of gene essentiality
(Elsevier B.V., 2008-02-01)
The identification of genes essential for survival is important for the understanding of the minimal requirements for cellular life and for drug design. As experimental studies with the purpose of building a catalog of ...
Genetic interactions of yeast eukaryotic translation initiation factor 5a (eIF5A) reveal connections to poly(A)-binding protein and protein kinase C signaling
(2002-03-14)
The highly conserved eukaryotic translation initiation factor eIF5A has been proposed to have various roles in the cell, from translation to mRNA decay to nuclear protein export. To further our understanding of this essential ...
Genetic interactions of yeast eukaryotic translation initiation factor 5a (eIF5A) reveal connections to poly(A)-binding protein and protein kinase C signaling
(2002-03-14)
The highly conserved eukaryotic translation initiation factor eIF5A has been proposed to have various roles in the cell, from translation to mRNA decay to nuclear protein export. To further our understanding of this essential ...
Use of a synthetic lethal screen to identify genes related to TIF51A in Saccharomyces cerevisiae
(2007-05-18)
The putative eukaryotic translation initiation factor 5A (eIF5A) is an essential protein for cell viability and the only cellular protein known to contain the unusual amino acid residue hypusine. eIF5A has been implicated ...
Use of a synthetic lethal screen to identify genes related to TIF51A in Saccharomyces cerevisiae
(2007-05-18)
The putative eukaryotic translation initiation factor 5A (eIF5A) is an essential protein for cell viability and the only cellular protein known to contain the unusual amino acid residue hypusine. eIF5A has been implicated ...