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ENDOTHELIN (16-21) - BIPHASIC EFFECT AND NO DESENSITIZATION ON THE GUINEA-PIG ISOLATED ILEUM
(Stockton Press, 1993-05-01)
1 In the guinea-pig ileum the C-terminal hexapeptide of the endothelins, endothelin (16-21), induced a biphasic effect (relaxation followed by contraction) qualitatively similar to that seen in the responses to endothelins ...
EFFECTS of ENDOTHELIN-3 ON the ISOLATED GUINEA-PIG ILEUM - ROLE of NA+ IONS and ENDOTHELIN RECEPTOR SUBTYPES
(Elsevier B.V., 1992-04-22)
Endothelin-3 induced a relaxation followed by contraction in the isolated guinea-pig ileum. the contractile but not the relaxant component of the response was concentration-dependent in the dose range studied. Neuronal ...
ROLE of POSITION-9 and POSITION-10 in the ENDOTHELIN MOLECULE for BIOLOGICAL-ACTIVITY and DISCRIMINATION of RECEPTOR SUBTYPES
(Elsevier B.V., 1995-05-15)
The importance of residues 9 and 10 in endothelin-1 was assessed by studying the responses of the guinea-pig ileum to [Ala(9)]endothelin-1 and [Ala(10)]endothelin-1. Both analogues induced relaxation followed by contraction. ...
Endothelin A receptor antagonist modulates lymphocyte and eosinophil infiltration, hyperreactivity and mucus in murine asthma
(ELSEVIER SCIENCE BV, 2008)
Levels of endothelins are particularly high in the lung, and there is evidence that these peptides are involved in asthma. Asthma is a chronic inflammatory disease associated with lymphocyte infiltration. In the present ...
HETEROGENOUS ENDOTHELIN RECEPTORS MEDIATE RELAXATION and CONTRACTION in the GUINEA-PIG ILEUM
(Elsevier B.V., 1995-10-24)
IRL1620, a specific endothelin ET(B) receptor agonist, induced relaxation followed by contraction in the guinea-pig ileum, as did endothelin-1. Both components of the response were concentration-dependent in the range ...