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Quick Detection of FKS1 Mutations Responsible for Clinical Echinocandin Resistance in Candida albicans
(American Society for Microbiology, 2015-07)
A rapid molecular-based assay for the detection of the Candida albicans FKS1 gene mutations responsible for resistance to echinocandin drugs was designed and evaluated. The assay consisted of a multiplexed PCR set of 5 ...
Improved Detection of Candida spp. fks Hot Spot Mutants by Using the Method of the CLSI M27-A3 Document with the Addition of Bovine Serum Albumin
(American Society For Microbiology, 2011-03)
Echinocandins are highly bound to serum proteins, altering their antifungal properties. The addition of 50% human serum to the MIC assay improves the identification of echinocandin-resistant Candida spp. harboring fks hot ...
Fitness and virulence costs of Candida albicans FKS1 hot spot mutations associated with echinocandin resistance
(University of Chicago Press, 2011-08)
The identification of FKS1 mutations in Candida albicans associated with echinocandin resistance has raised concerns over the spread of drug-resistant strains. We studied the impact of fks1 mutations on C. albicans virulence ...
Evaluation of fungal-specific fluorescent labeled echinocandin probes as diagnostic adjuncts
(Oxford University Press, 2013-01)
The diagnosis of invasive fungal infections from radiographic imaging is non-specific and problematic. As a first step toward increasing specificity, we describe the development of a broad-spectrum fungal-specific targeting ...
Molecular Confirmation of the Relationship between Candida guilliermondii Fks1p Naturally Occurring Amino Acid Substitutions and Its Intrinsic Reduced Echinocandin Susceptibility
(American Society for Microbiology, 2017-05)
C. guilliermondii shows intrinsic reduced echinocandin susceptibility. It harbors two polymorphisms (L633M and T634A) at the Fks1p hot-spot 1 region. Our objective was to confirm that C. guilliermondii´s reduced echinocandin ...
Phenotypic and molecular evaluation of echinocandin susceptibility of Candida glabrata, Candida bracarensis, and Candida nivariensis strains isolated during 30 years in Argentina
(American Society for Microbiology, 2017-07)
The echinocandin susceptibilities of 122 Candida glabrata complex strains (including 5 Candida nivariensis and 3 Candida bracarensis strains) were evaluated by microdilution and compared with the results from a molecular ...
Biological Properties and Analytical Methods for Micafungin: A Critical Review
(2020-01-01)
Micafungin is characterized as one of the most active available drugs for candidemia treatment; however, their use is also associated in prophylaxis protocols in cases of invasive fungal infections. The use of this drug ...
Rezafungin—mechanisms of action, susceptibility and resistance: Similarities and differences with the other echinocandins
(MDPI AG, 2020-12)
Rezafungin (formerly CD101) is a new β-glucan synthase inhibitor that is chemically related with anidulafungin. It is considered the first molecule of the new generation of long-acting echinocandins. It has several advantages ...
Subunidades Fksp del complejo beta-1,3- D-glucan sintasa de Candida glabrata: rol en la síntesis de la pared celular, en la resistencia a las equinocandinas y como marcadores de resistencia clínica
(2017-03-17)
Las infecciones causadas por levaduras del complejo Candida glabrata son un desafío terapéutico, ya que adquieren fácilmente resistencia a los triazoles y tienen sensibilidad reducida a los polienos. Por estas razones, las ...