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Drug Transporters
(Springer Nature Switzerland AG, 2018)
Membrane transporters perform a central function in many essential body functions, including traffic and compartmentalization of physiologic compounds, absorption of physiologic compounds (and, occasionally, structurally ...
Computer-Aided Drug Design: An Overview
(Humana Press, 2018)
The term drug design describes the search of novel compounds with biological activity, on a systematic basis. In its most common form, it involves modification of a known active scaffold or linking known active scaffolds, ...
Flunitrazepam–Membrane Binding: A Sensor for Drug-Induced GABAA-R and Membrane Structure Changes
(Elsevier Academic Press Inc., 2016)
Flunitrazepam (FNZ) is a sedative–hypnotic benzodiazepine with important therapeutic usefulness and significant abuse liability. Its capability to induce anterograde amnesia favors FNZ use as a “date-rape drug” administered ...
Stimuli-Responsive Polymeric Systems for Smart Drug Delivery
(Springer, 2020)
This chapter provides a general description of smart drug delivery systems (DDSs) based on the use of stimuli-responsive polymers. Smart DDSs have the distinctiveness of carrying out the release of therapeutics at the ...
Nanotechnology Applications in Drug Controlled Release
(Elsevier, 2018)
Nanotechnology is the manipulation of matter, involving physical and chemicaltransformations, in order to produce materials at the nanoscale. The word nano,which derives from Latin, signifies dwarf and mathematically is ...
Virtual Screening Applications in the Search of Novel Antiepileptic Drug Candidates
(Springer, 2016)
Virtual screening (VS) encompasses a wide spectrum of computational approaches oriented to prioritize which compounds from chemical libraries or repositories will be subjected to experimental in vitro and in vivo testing. ...
Structural characteristics of the TPR Protein-Hsp90 interaction: A new target in biotechnology
(Bentham Science Publishers, 2018)
Nature employs multiple repeat protein scaffolds in order to promote proteinprotein interactions. In this sense, TPR proteins participate in different natural pathways, especially in diverse processes of eukaryotic cells. ...
Selected aspects of the chemical and biological profile of triclabendazole: A widely used benzimidazole fasciolicidal agent
(Nova Science Publishers, 2019)
Fasciolosis is a very serious parasiticdisease, caused by Fasciola hepaticaand Fasciola gigantica, which isresponsible for heavy economic losses in the production of sheep and cattle inmany countries around the world. In ...
Introductory Chapter: Liposomes - Advances and Perspectives - My Point of View
(IntechOpen, 2019)
Liposomes are vesicular arrangements composed of one or more phospholipid bilayers surrounding an aqueous core. Liposomes were discovered almost six decades ago. Due to its versatility, liposomes are now analyzed for their ...
Crosstalk between DNA methylation chromatin structure
(Elsevier, 2016)
Regulation of gene expression is the result of a functional crosstalk between multiple epigenetic pathways. DNA methylation is an epigenetic mark that is typically related to gene silencing. Changes in DNA methylation are ...