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Inhibition of Myotoxic Activity of Bothrops asper Myotoxin II by the Anti-trypanosomal Drug Suramin
(2005-06-15)
Suramin, a synthetic polysulfonated compound, developed initially for the treatment of African trypanosomiasis and onchocerciasis, is currently used for the treatment of several medically relevant disorders. Suramin, ...
Crystal structure of a phospholipase A2 from Bothrops asper venom: Insights into a new putative “myotoxic cluster”
(2017)
Snake venoms from the Viperidae and Elapidae families often have several phospholipases A2 (PLA2s),
which may display different functions despite having a similar structural scaffold. These proteins are
considered an ...
Substance use disorder comorbidity with schizophrenia in families of Mexican and Central American Ancestry
(Schizophrenia Research 120 (2010) 87–94, 2010)
Objectives:The aims of this study were to estimate the frequency and course of substances use disorders in Latino patients with schizophrenia and to ascertain risk factors associated with substance use disorders in this ...
Skeletal muscle necrosis induced by a phospholipase A2 isolated from the venom of the coral snake Micrurus nigrocinctus nigrocinctus.
(1987)
1. The venom of the coral snake Micrurus nigrocinctus nigrocinctus was fractionated by reverse-phase high performance liquid chromatography and an acidic myotoxic phospholipase A2 was purified to homogeneity. 2. After ...
From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy
(2016)
The snake is the symbol of medicine due to its association with Asclepius, the
Greek God of medicine, and so with good reasons. More than 725 species of venomous
snakes have toxins specifically evolved to exert potent ...
The oxidative metabolism of sparteine in the Cuna Amerindians of Panama: Absence of evidence for defient metabolizers
(1988-04-20)
Sparteine sulfate (50 mg) was administered to 170 Cuna Amerindians, 142 of whom were unrelated, and the drug and its dehydrometabolites were determined in the 0- to 12-hour urine samples. The log10 of the metabolic ratio ...
Synthetic peptides derived from the C-terminal region of Lys49 phospholipase A2 homologues from Viperidae snake venoms: biomimetic activities and potential applications
(2010)
Lys49-phospholipase A2 homologues constitute a large family of toxins present in the venoms of viperid snake species, which
despite lacking catalytic activity, cause significant skeletal muscle necrosis. The main structural ...
The CDRC Principles of International Health Research
(Journal of Urban Health 82 (3)p.5-8 suplemento 4, 2005)
The Comprehensive Drug Research Center (CDRC) at the University of Miami was established in the early 1970s. Through the decades, investigators from the CDRC have worked with investigators from several countries to establish ...
Medicinal plants with inhibitory properties against snake venoms
(2005)
Envenomations due to snake bites are commonly treated by parenteral administration of horse or
sheep-derived polyclonal antivenoms aimed at the neutralization of toxins. However, despite the widespread
success of this ...
Screening for target toxins of the antiophidic protein DM64 through a gel-based interactomics approach
(2017-01)
DM64 is a glycosylated protein with antivenomactivity isolated fromthe serum of the opossumDidelphis aurita.
It binds non-covalently to myotoxins I (Asp49) and II (Lys49) from Bothrops asper venom and inhibits their
myotoxic ...