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Interaction between DNA and drugs having protonable basic groups: Characterization through affinity constants, drug release kinetics, and conformational changes
(MDPI AG, 2017-03-04)
This paper reports the in vitro characterization of the interaction between the phosphate groups of DNA and the protonated species of drugs with basic groups through the determination of the affinity constants, the ...
N,N-Dimethylacrylamide Hydrogels for Controlled Drug Delivery. Influence of Network Structure and Drug Solubility on the Load and Release Mechanisms
(Planta Piloto de Ingeniería Química, 2019-08)
The aim of the present work was to synthesize sustained-release hydrogels based on N,N-dimethylacrylamide (DMA) to study the effect of the polymer matrix structure and the solubility of drugs on the load and release ...
Drug transfer into target helminth parasites
(Elsevier, 2007-03)
The pharmacokinetics of an anthelmintic drug includes the time course of drug absorption, distribution, metabolism and elimination from the host and determines the concentration of the active drug that reaches the location ...
Correlation between assembly structure of a gamma irradiated albumin nanoparticle and its function as a drug delivery system
(Elsevier Science, 2020-10)
The present study correlates the structure of an albumin nanoparticle with its function as a drug delivery system. The albumin nanoparticle was created by a clean and size-controlled desolvation method in combination with ...
Comparative study of three structurally related acid polyelectrolytes as carriers of basic drugs: Carbomer, Eudragit L 100 and Eudragit S 100
(Taylor & Francis Ltd, 2010-05)
A detailed description of equilibrium and drug release properties of aqueous dispersions of complexes of model basic drugs (D) with three structurally related acid polyelectrolytes (PE) is reported. Thus, equilibrium ...
Artificial Itelligence Teaches Drugs to Target Proteins by Tackling the Induced Folding Problem
(American Chemical Society, 2020-06-17)
We explore the possibility of a deep learning (DL) platform that steers drug design to target proteins by inducing binding-competent conformations. We deal with the fact that target proteins are usually not fixed targets ...
Quantum chemical approaches in structure-based virtual screening and lead optimization
(Frontiers Research Foundation, 2018-05)
Today computational chemistry is a consolidated tool in drug lead discovery endeavors. Due to methodological developments and to the enormous advance in computer hardware, methods based on quantum mechanics (QM) have gained ...
Therapeutic drug monitoring in developing nations: Assessing the current state of affairs in South America
(Taylor & Francis, 2021-01)
Therapeutic drug monitoring (TDM) aims to offer assistance to clinicians to improve drug dosing and clinical outcomes, while minimizing the probability of serious adverse effects in routine clinical practice. Disease ...
Crosslinked casein-based micelles as a dually responsive drug delivery system
(Royal Society of Chemistry, 2018-07-30)
New types of biodegradable nanocarriers for drug delivery were prepared using casein (CAS) micelles as particle templates and glyceraldehyde (GAL) as a crosslinking agent. We found that highly crosslinked casein micelles ...
Computational and synthetic target-based approaches to the discovery of novel anticonvulsant compounds
(Bentham Science Publishers, 2021-05)
Background: During the past decades, an important number of anticonvulsant drugs have been incorporated into the collection of drugs to treat epilepsy. However, two main difficulties remain unsolved in therapy: the development ...