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A review of pharmacokinetic parameters of metabolites and prodrugs
(Drug Metabolism Letters, 2014)
In drug discovery and development, the kinetic study of active metabolites plays an important role, helping to define the time course of the drug in the body and its activity or toxicity. After a pharmacokinetics assessment ...
A review of pharmacokinetic parameters of metabolites and prodrugs
(2013-01-01)
In drug discovery and development, the kinetic study of active metabolites plays an important role, helping to define the time course of the drug in the body and its activity or toxicity. After a pharmacokinetics assessment ...
Combined data mining strategy for the systematic identification of sport drug metabolites in urine by liquid chromatography time-of-flight mass spectrometry
(Elsevier Science, 2013-01-25)
The development of comprehensive methods able to tackle with the systematic identification of drug metabolites in an automated fashion is of great interest. In this article, a strategy based on the combined use of two ...
Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson's disease
(Frontiers Media S.A., 2015)
The importance of bioactivation in computer-guided drug repositioning: Why the parent drug is not always enough
(Bentham Science Publishers, 2016-08)
Although bioactivation is a well-documented process and the role of active metabolites in the drug discovery field has long been recognized, drug metabolites are usually ignored in virtual screening campaigns oriented to ...
A review of pharmacokinetic parameters of metabolites and prodrugs
(Drug Metabolism Letters, 2015)
A review of pharmacokinetic parameters of metabolites and prodrugs
(Drug Metabolism Letters, 2015)
New pioglitazone metabolites and absence of opened-ring metabolites in new n-substituted thiazolidinedione
(2018-06-01)
Thiazolidinediones (TZDs) are drugs used to treat type 2 diabetes mellitus; however, several safety concerns remain regarding the available drugs in this class. Therefore, the search for new TZD candidates is ongoing; ...
Ethnobiology and Ethnopharmacology of Lepidium meyenii (Maca), a Plant from the Peruvian Highlands.
(Hindawi, 2012)
Lepidium meyenii (maca) is a Peruvian plant of the Brassicaceae family cultivated for more than 2000 years, which grows exclusively in the central Andes between 4000 and 4500 m altitude. Maca is used as a food supplement ...
Application of in vitro Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP)
(Frontiers Media Sa, 2019-04-24)
Currently no approved treatment exists for fibrodysplasia ossificans progressiva (FOP) patients, and disease progression results in severe restriction of joint function and premature mortality. LDN-193189 has been demonstrated ...