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Multiscale boundary conditions for non-Fickian diffusion applied to drug-eluting stents
(2017-01-01)
We propose a multiscale model for the study of blood flow, plasma filtration, and non-Fickian mass transport by a coronary drug-eluting stent. We derive an analytic solution of a one-dimensional model for non-Fickian ...
Modeling of non-Fickian diffusion and dissolution from a thin polymeric coating: An application to drug-eluting stents
(2018-04-20)
In this paper, we present a general model for non-Fickian diffusion and drug dissolution from a controlled drug delivery device coated with a thin polymeric layer. First, we study the stability and deduce an analytic ...
Encapsulação da rifampicina em matrizes poliméricas flutuantes obtidas por liofilização a partir de metilcelulose e ftalato de hidroxipropilmetilcelulose. Avaliação da liberação in vitro
(2001-12-01)
Floating multiparticles for oral administration with different compositions were studied from a matricial polymeric system to obtain sustained release. The polymers used in the multiparticles constitution were methylceullose ...
Diffusion of nitroglycerin from drug delivery patches through micro-fibre filters using Fourier transform infrared photoacoustic spectrometry
(2001)
In this paper, the diffusion of the angina therapeutic agent, nitroglycerin through a skin mimetic is described. The mimetic is a poly(ethylene) glycol loaded microfibre filter to which a transdermal drug patch is attached. ...
Two-dimensional transport analysis of transdermal drug absorption with a non-perfect sink boundary condition at the skin-capillary interface
(ELSEVIER SCIENCE INC, 2013-07-01)
A transient percutaneous drug absorption model was solved in two dimensions. Clearance of the topically-applied pharmaceutical occured at the skin-capillary boundary. Timolol penetration profiles in the dermal tissue were ...
Influence of non-Newtonian blood flow models on drug deposition in the arterial wall
(2019-12-01)
In this paper, we investigate the influence of non-Newtonian blood flow models on drug diffusion from a coronary drug-eluting-stent (DES). We consider the Oldroyd-B, Phan-Thien-Tanner (PTT) and Giesekus viscoelastic models ...
On a dissolution-diffusion model. Existence, uniqueness, regularity and simulations
(Elsevier, 2015-10)
We perform a mathematical analysis of a model for drug dissolution-diffusion in non erodible nor swellable devices. We deduce a model and obtain a coupled nonlinear system which contains a parabolic equation for the dissolved ...
Validation of microbiological assay for determination of cefuroxime in injectable preparations
(2012-08-22)
The validation of a microbiological assay, applying agar diffusion method for determination of the active of cefuroxime in power for injection, is described. Using a strain of Micrococcus luteus ATCC 9341 as the test ...