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Computer-Aided Drug Design: An Overview
(Humana Press, 2018)
The term drug design describes the search of novel compounds with biological activity, on a systematic basis. In its most common form, it involves modification of a known active scaffold or linking known active scaffolds, ...
Drug Transporters
(Springer Nature Switzerland AG, 2018)
Membrane transporters perform a central function in many essential body functions, including traffic and compartmentalization of physiologic compounds, absorption of physiologic compounds (and, occasionally, structurally ...
The efficiency of multi-target drugs: A network approach
(Springer, 2020)
Multi-target agents have attracted great attention in the last 15 years, as they are expected to provide more efficacious and safer therapeutic solutions, less prone to drug resistance phenomena. They thus seem particularly ...
In silico modeling of FDA-approved drugs for discovery of therapies against neglected diseases: A drug repurposing approach
(Elsevier, 2019)
Drug repurposing (i.e., finding new therapeutic uses for already known drugs, including approved, abandoned, discontinued, and investigational drugs) is being extensively applied worldwide to expedite the development of ...
Polyelectrolyte-drug ionic complexes as nanostructured drug carriers to design solid and liquid oral delivery systems
(Elsevier, 2017)
Aqueous dispersions of acid or basic polyelectrolytes (PE) loaded with ionizable drugs (D) of opposite charge are characterized by a high degree of counterionic condensation. In solid state, these PE-D complexes are stable ...
Exploring Protein-Protein Interactions as Drug Targets for Anti-cancer Therapy with In Silico Workflows
(Humana Press, 2017)
We describe a computational protocol to aid the design of small molecule and peptide drugs that target protein-protein interactions, particularly for anti-cancer therapy. To achieve this goal, we explore multiple strategies, ...
Stimuli-responsive polymersomes for drug delivery applications
(Elsevier, 2019)
There is a considerable research interest in polymers for drug delivery systems in the medical and pharmaceutical field. Several polymeric materials have been investigated in the development of nanostructures for drug ...
Drug distribution
(Springer, 2018)
Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. ...
Drug Metabolism
(Springer, 2018)
Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. ...
Drug Absorption
(Springer, 2018)
Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. ...