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Sedative and antinociceptive effects of different combinations of detomidine and methadone in standing horses
(2017-09-01)
Objective To evaluate intravenous (IV) detomidine with methadone in horses to identify a combination which provides sedation and antinociception without adverse effects. Study design Randomized, placebo-controlled, blinded, ...
Sedative effect and physiological changes in horses treated with intramuscular injection of detomidine and morphine
(Univ Federal Santa Maria, 2022-01-01)
This study aimed to elucidate the sedative effect and physiological changes associated with the intramuscular injection of detomidine combined with morphine in horses. Six healthy crossbred horses, aged 2 to 10 years, were ...
Comparative study between atropine and hyoscine-N-butylbromide for reversal of detomidine induced bradycardia in horses
(Wiley-Blackwell, 2011-05-01)
P>Reasons for performing study:Bradycardia may be implicated as a cause of cardiovascular instability during anaesthesia.Hypothesis:Hyoscine would induce positive chronotropism of shorter duration than atropine, without ...
Intravenous anaesthesia using detomidine, ketamine and guaiphenesin for laparotomy in pregnant pony mares
(2001-01-01)
Objective To characterize intravenous anaesthesia with detomidine, ketamine and guaiphenesin in pregnant ponies. Animals Twelve pony mares, at 260–320days gestation undergoing abdominal surgery to implant fetal and maternal ...
A possible solution to model nonlinearity in elimination and distributional clearances with α2-adrenergic receptor agonists: Example of the intravenous detomidine and methadone combination in sedated horses
(2019-11-01)
The alpha(α)2-agonist detomidine is used for equine sedation with opioids such as methadone. We retrieved the data from two randomized, crossover studies where detomidine and methadone were given intravenously alone or ...
Characterisation of the in vivo interactions between detomidine and methadone in horses: Pharmacokinetic and pharmacodynamic modelling
(2019-07-01)
Background: Pharmacokinetic (PK)/pharmacodynamic (PD) modelling offers new insights to design protocols for sedation and analgesia in standing horses. Objectives: To evaluate the parameters and interactions between detomidine ...
Protocols using detomidine and oxytocin induce ex copula ejaculation in stallions
(2019-12-01)
Tricyclic antidepressives, such as imipramine, indirectly induce ejaculation by increasing the noradrenaline concentration, which triggers an α-adrenergic response, whereas α-adrenergic agonists, such as xylazine and ...
Atipamezole antagonism of an ACTH stimulation test in ponies sedated with detomidine
(Wiley-Blackwell, 2011-10-01)
Comparison of detomidine/ketamine and guaiphenesin/thiopentone for induction of anaesthesia in horses maintained with halothane
(1998-05-16)
This prospective clinical study compared the physiological effects of two commonly used anaesthetic induction techniques in horses maintained with halothane. One hundred horses admitted for elective surgery were randomly ...
ANTINOCICEPTIVE EFFECT OF AMITRAZ IN MICE AND RATS
(Associação Brasileira de Divulgação Científica (ABRADIC), 1994-06-01)
Amitraz, a formamidine insecticide and acaricide used in veterinary practice, presents side effects related to its pharmacological activity on az-adrenergic receptors. The present study was undertaken to investigate the ...