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Sedative and antinociceptive effects of different combinations of detomidine and methadone in standing horses
(2017-09-01)
Objective To evaluate intravenous (IV) detomidine with methadone in horses to identify a combination which provides sedation and antinociception without adverse effects. Study design Randomized, placebo-controlled, blinded, ...
Sedative effect and physiological changes in horses treated with intramuscular injection of detomidine and morphine
(Univ Federal Santa Maria, 2022-01-01)
This study aimed to elucidate the sedative effect and physiological changes associated with the intramuscular injection of detomidine combined with morphine in horses. Six healthy crossbred horses, aged 2 to 10 years, were ...
Comparative study between atropine and hyoscine-N-butylbromide for reversal of detomidine induced bradycardia in horses
(Wiley-Blackwell, 2011-05-01)
P>Reasons for performing study:Bradycardia may be implicated as a cause of cardiovascular instability during anaesthesia.Hypothesis:Hyoscine would induce positive chronotropism of shorter duration than atropine, without ...
Comparative study between atropine and hyoscine-N-butylbromide for reversal of detomidine induced bradycardia in horses
(Wiley-Blackwell, 2011-05-01)
P>Reasons for performing study:Bradycardia may be implicated as a cause of cardiovascular instability during anaesthesia.Hypothesis:Hyoscine would induce positive chronotropism of shorter duration than atropine, without ...
Intravenous anaesthesia using detomidine, ketamine and guaiphenesin for laparotomy in pregnant pony mares
(2001-01-01)
Objective To characterize intravenous anaesthesia with detomidine, ketamine and guaiphenesin in pregnant ponies. Animals Twelve pony mares, at 260–320days gestation undergoing abdominal surgery to implant fetal and maternal ...
Evaluation of the effect of hyoscine-N-butyl bromide on the cardiovascular actions of detomidine in the horse
(Universidade de São Paulo (USP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), 2014)
A possible solution to model nonlinearity in elimination and distributional clearances with α2-adrenergic receptor agonists: Example of the intravenous detomidine and methadone combination in sedated horses
(2019-11-01)
The alpha(α)2-agonist detomidine is used for equine sedation with opioids such as methadone. We retrieved the data from two randomized, crossover studies where detomidine and methadone were given intravenously alone or ...
Characterisation of the in vivo interactions between detomidine and methadone in horses: Pharmacokinetic and pharmacodynamic modelling
(2019-07-01)
Background: Pharmacokinetic (PK)/pharmacodynamic (PD) modelling offers new insights to design protocols for sedation and analgesia in standing horses. Objectives: To evaluate the parameters and interactions between detomidine ...