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Fatigue damage accumulation in aluminum 7050-T7451 alloy subjected to block programs loading under step-down sequence
(Elsevier B.V., 2010-01-01)
In this paper the fatigue damage accumulation under block program loading is investigated. Alternative flexion bending fatigue tests with a single change in stress amplitude are performed at room temperature for step-down ...
The role of mitochondrial DNA damage in the citotoxicity of reactive oxygen species
(SPRINGER/PLENUM PUBLISHERS, 2011)
Mitochondria contain their own genome, a small circular molecule of around 16.5 kbases. The mitochondrial DNA (mtDNA) encodes for only 13 polypeptides, but its integrity is essential for mitochondrial function, as all 13 ...
Cell death induced by mitochondrial complex I inhibition is mediated by Iron Regulatory Protein 1
(Elsevier B.V., 2017)
© 2017 Elsevier B.V. Mitochondrial dysfunction and oxidative damage, often accompanied by elevated intracellular iron levels, are pathophysiological features in a number of neurodegenerative processes. The question arises ...
Iron-induced oxidative damage in colon carcinoma (Caco-2) cells
(Harwood Academic Publishers GmbH, 2001)
Intestinal epithelial cells have an active apical iron uptake system that is involved in the regulated absorption of iron. By the action of this system, intestinal cells acquire increasing amounts of iron with time. Since ...
Influence of tire sizes over automobile body spectrum loads and fatigue damage accumulation
(ElsevierOxford, 2015-02)
Design specifications in automobile project and construction lead, in recent models, to the preference of using increasingly larger and slender tires. The tire and wheel set, however, is instrumental in determining the ...
The novel mitochondrial iron chelator 5-((methylamino)methyl)-8-hydroxyquinoline protects against mitochondrial-induced oxidative damage and neuronal death
(Elsevier, 2015)
Abundant evidence indicates that iron accumulation, oxidative damage and mitochondrial dysfunction are common features of Huntington's disease, Parkinson's disease, Friedreich's ataxia and a group of disorders known as ...
Damage Accumulation in Silica Glass Nanofibers
(American Chemical Society, 2018-07)
The origin of the brittle-to-ductile transition, experimentally observed in amorphous silica nanofibers as the sample size is reduced, is still debated. Here we investigate the issue by extensive molecular dynamics simulations ...
Parkinson’s Disease: The Mitochondria-Iron Link
(Hindawi Publishing Corp, 2016)
Mitochondrial dysfunction, iron accumulation, and oxidative damage are conditions often found in damaged brain areas of Parkinson's disease. We propose that a causal link exists between these three events. Mitochondrial ...