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SLAM and CD31: signaling molecules involved in cytokine secretion during the development of innate and adaptive immune responses
(Elsevier, 2007-02)
Immune cells are modulated through the crosslinking of receptors named “immunoreceptors”. Ligation of immunoreceptors by their ligands induces a tyrosine-phosphorylation signal that is essential for cell activation or ...
Follicular structures of cows with cystic ovarian disease present altered expression of cytokines
(Cambridge University Press, 2019-08)
Ovulation is considered an inflammatory, cytokine-mediated event.Cytokines, which are recognized as growth factors with immunoregulatory properties, are involved in many cellular processes at the ovarian level. In this ...
Immunohistochemical detection of pro-inflammatory and anti-inflammatory cytokines in granulomas in cattle with natural Mycobacterium bovis infection
(Elsevier, 2017-02)
Cellular immune response was evaluated in lymph nodes and lung with different granulomatous lesions from cattle naturally infected with Mycobacterium bovis. For this purpose, we assessed pro-inflammatory and anti-inflammatory ...
Amino acid residues involved in the heparin-binding activity of murine IL-12 in the context of an antibody-cytokine fusion protein
(Academic Press Ltd - Elsevier Science Ltd, 2019-08)
An antibody-cytokine fusion protein, composed of the murine single-chain cytokine interleukin-12 (IL-12) genetically fused to a human IgG3 specific for the human tumor-associated antigen HER2/neu maintains antigen binding, ...
Cytokines, antibodies, and histopathological profiles during Giardia infection and variant-specific surface proteinbased vaccination
(American Society for Microbiology, 2018-06)
Giardiasis is one of the most common human intestinal diseases worldwide. Several experimental animal models have been used to evaluate Giardia infections, with gerbils (Meriones unguiculatus) being the most valuable model ...
SLAM and CD31: Signaling molecules involved in cytokine secretion during the development of innate and adaptive immune responses
(Elsevier, 2007-02)
Immune cells are modulated through the crosslinking of receptors named "immunoreceptors". Ligation of immunoreceptors by their ligands induces a tyrosine-phosphorylation signal that is essential for cell activation or ...
Effects of tomato extract on cytokine profile of human peripheral blood mononuclear Cells (PBMCs)
(2016)
Objective: This study was aimed to evaluate the effect of the addition of tomato extract (TE) on cytokine production.
Conclusion: In the in vitro system performed in this study, a physiological amount of α-tocopherol ...
Cytokine-enhanced vaccine and suicide gene therapy as adjuvant treatments of metastatic melanoma in a horse
(British Veterinary Association, 2009-02)
We evaluated the safety, efficacy and anti-tumour effects of a surgery adjuvant treatment on an equine patient with metastatic malignant melanoma. This approach combined suicide gene therapy with a subcutaneous vaccine ...
CD4+ and CD8+ T cells producing Th1 and Th17 cytokines are involved in the pathogenesis of autoimmune orchitis
(BioScientifica, 2011-02)
Experimental autoimmune orchitis (EAO) is a useful model to study chronic testicular inflammation and infertility. EAO is characterized by severe damage of seminiferous tubules with germ cells that undergo apoptosis and ...
Characteristic pro-inflammatory cytokines and host defence cathelicidin peptide produced by human monocyte-derived macrophages infected with Neospora caninum
(Cambridge University Press, 2018-06)
Neospora caninum is a coccidian intracellular protozoan capable of infecting a wide range of mammals, although severe disease is mostly reported in dogs and cattle. Innate defences triggered by monocytes/macrophages are ...