Now showing items 1-10 of 544
Evaluation of cytochrome P-450 concentration in Saccharomyces cerevisiae strains
(Universidade de São Paulo, Faculdade de Ciências Farmacêuticas, 2010)
Saccharomyces cerevisiae has been widely used in mutagenicity tests due to the presence of a cytochrome P-450 system, capable of metabolizing promutagens to active mutagens. There are a large number of S. cerevisiae strains ...
Modulation of rat liver cytochrome P450 activity by prolonged red wine consumption
Cytochrome P450-dependent oxidation of lauric acid, p-nitrophenol and ethanol by liver microsomal fractions were studied in control rats and in animals given either ethanol, red wine, or alcohol-free red wine for 10 weeks. ...
Purification and characterization of liver cytochrome P-446 isolated from protein energy malnourished rats
(Kluwer Academic Publishers, 1988)
A liver cytochrome P-450 isozyme has been purified to homogeneity from protein-energy malnourished rats induced with β-naphthoflavone (β-NF). The purification steps included chromatography on DEAE-Sephadex-A-25, DEAE-cellulose ...
Effect of two wheat cultivars differing in hydroxamic acid concentration on detoxification metabolism in the aphid Sitobion avenae
Hydroxamic acids (Hx) are wheat secondary metabolites conferring resistance for cereals against aphids. The activity of five enzymatic systems were evaluated in the aphid Sitobion avenae reared on the high-Hx wheat cultivar ...
Inhibition of Rat Brain Microsomal Cytochromes P450-dependent Dealkylation Activities by an Oxidative Stress
(Neurotoxicity Research, 2001-07)
Characterization of the cytochrome P450 monooxygenase genes (P450ome) from the carotenogenic yeast Xanthophyllomyces dendrorhous
(BIOMED Central Ltd., 2017)
Background: The cytochromes P450 (P450s) are a large superfamily of heme-containing monooxygenases involved in the oxidative metabolism of an enormous diversity of substrates. These enzymes require electrons for their ...
Mechanisms underlying the inhibition of the cytochrome P450 system by copper ions
Copper toxicity has been associated to the capacity of free copper ions to catalyze the production of superoxide anion and hydroxyl radical, reactive species that modify the structure and/or function of biomolecules. In ...
Melatonin protects the cytochrome P450 system through a novel antioxidant mechanism
Melatonin, an endogenous hormone, is used as an antioxidant drug in doses quite higher than the endogenous circulating levels of this hormone. Hepatic endoplasmic reticulum contains the cytochrome P450 (CYP450) system, ...
Identification of the transcriptionally active cytochrome P450 repertoire in Coffea arabica.
(Genetics and Molecular Research, v. 14, n. 1, p. 2399-2412, 2015, 2015)
Modulation of cytochrome P450 activity in the kidney of rats following long-term red wine exposure
Cytochrome P450 (CYP)-dependent oxidation of lauric acid, p-nitrophenol and ethanol by microsomal fractions of kidney were studied in control rats and in animals given either ethanol, red wine, or alcohol-free red wine for ...