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Protein kinase CK2 promotes cancer cell viability via up-regulation of cyclooxygenase-2 expression and enhanced prostaglandin E2 production
(2011)
Augmented expression of protein kinase CK2 is associated with hyperproliferation and resistance to apoptosis in cancer cells. Effects of CK2 are at least partially linked to signaling via the Wnt/β-catenin pathway, which ...
Meloxicam decreases the migration and invasion of CF41.Mg canine mammary carcinoma cells
(Spandidos Publications Ltd., 2017)
Cyclooxygenase (COX)-2 expression is positively correlated with malignant features in canine mammary carcinomas. Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit COX activity and may therefore possess anticancer ...
Copper oxide nanoparticles recruit macrophages and modulate nitric oxide, proinflammatory cytokines and PGE(2) production through arginase activation
(Future Medicine, 2016)
Aim: In the present study, we examine the effects of copper oxide nanoparticles (CuNP) on macrophage immune response and the signaling pathways involved. Materials & Methods: A peritonitis model was used to determine in ...
Spinal synergy between nonselective cyclooxygenase inhibitors and morphine antinociception in mice
(ELSEVIER SCIENCE, 2005-07-12)
The antinociception induced by the intrathecal coadministration of combinations of morphine with the nonsteroidal anti-inflammatory drugs (NSAIDs) naproxen, piroxicam, metamizol, diclofenac and ketoprofen was studied by ...
Genetic polymorphisms as non-modifiable susceptibility factors to laryngeal cancer
(Portland Press, 2020)
Laryngeal squamous cell carcinoma (LSCC) is a highly disabling disease to the patient, affecting speech, swallowing and respiratory skills. Smoking and alcohol abuse are principal risk factors linked to this disease. Genetic ...
Caveolin-1-mediated suppression of cyclooxygenase-2 via a β-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin e2 production and survivin expression
(2009)
Augmented expression of cyclooxygenase-2 (COX-2) and enhanced production of prostaglandin E2 (PGE2) are associated
with increased tumor cell survival and malignancy. Caveolin-1 is a scaffold protein that has been proposed ...
Endoglin regulates cyclooxygenase-2 expression and activity
(LIPPINCOTT WILLIAMS & WILKINS, 2006-08-04)
The endoglin heterozygous (Eng(+/-)) mouse, which serves as a model of hereditary hemorrhagic telangiectasia (HHT), was shown to express reduced levels of endothelial NO synthase (eNOS) with impaired activity. Because of ...
Expression profiles of the progesterone receptor, cyclooxygenase-2, growth differentiation factor 9, and bone morphogenetic protein 15 transcripts in the canine oviducts during the oestrous cycle
(MDPI, 2021)
The oestrous cycle in canines is specifically more extended than that in other mammals. This implies that the oocytes do not reach maturity within the ovarian follicle but undergo final maturation in the oviducts. Besides ...
Angiogenesis and tumor progression inhibition of cyclooxygenase-2 selective inhibitor celecoxib associated with poly (lactic-co-glycolic acid) in tumor cell line resistant to chemotherapy
(Sociedad Chilena de Anatomía, 2017)
Although, antineoplastic therapies have now been developed reduction of tumor progression, it is necessary to find new therapeutic alternatives to suppress angiogenesis. Thus celecoxib (Cx) has been used for its antiangiogenic ...
Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism
(1988)
A new generation of heteroatom analogs of arachidonic acid are documented as powerful and selective inhibitors of the cytochrome P-450-dependent arachidonic acid oxygenase reaction (IC50, 5-10 μm) with little effect on ...