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The corticotropin-releasing hormone network and the hypothalamic-pituitary- adrenal axis: Molecular and cellular mechanisms involved
(Karger, 2011-07)
Corticotropin-releasing hormone (CRH) plays a key role in adjusting the basal and stress-activated hypothalamic-pituitary-adrenal axis (HPA). CRH is also widely distributed in extrahypothalamic circuits, where it acts as ...
The central nervous system acts as a transducer of stress-induced masculinization through corticotropin-releasing hormone b
(Company of Biologists, 2019-04)
Exposure to environmental stressors, like high temperature (HT), during early development of fish induces sex reversal of genotypic females. Nevertheless, the involvement of the brain in this process is not well clarified. ...
Ghrelin activates hypophysiotropic corticotropin-releasing factor neurons independently of the arcuate nucleus
(Pergamon-Elsevier Science Ltd, 2016-05)
Previous work has established that the hormone ghrelin engages the hypothalamic-pituitary-adrenal neuroendocrine axis via activation of corticotropin-releasing factor (CRF) neurons of the hypothalamic paraventricular nucleus ...
A fluorescence nanoscopy marker for corticotropin-releasing hormone type 1 receptor: Computer design, synthesis, signaling effects, super-resolved fluorescence imaging, and: In situ affinity constant in cells
(Royal Society of Chemistry, 2018-11)
Class B G protein-coupled receptors (GPCRs) are involved in a variety of human pathophysiological states. These groups of membrane receptors are less studied than class A GPCRs due to the lack of structural information, ...
Direct effect of melatonin on Syrian Hamster testes: Mel1a receptors, inhibition on androgen production, and interaction with the local corticotropin-releasing hormone (CRH) system
(Endocrine Society, 2005-03-01)
Besides the hypothalamus and pituitary, melatonin action at the testicular level has been recently suggested. Therefore, we investigated in the Syrian hamster, a well-characterized seasonal breeder, melatonin action on ...
Sexual dimorphism of neuroendocrine-immune interactions
(Karger, 2002-12)
In the bidirectional interplay between the immune and endocrine systems, the communications most deeply investigated up to now have been those between the immuhC:and the hypothalamo-pituita~y-adrenal (HPA) and the HP-gonadal ...
Lifelong Aerobic Exercise Reduces the Stress Response in Rats
(Pergamon-Elsevier Science Ltd, 2018-04)
The aim of this study was to analyze the effects of lifelong aerobic exercise (AE) on the adaptive response of the stress system in rats. It is well known that hypothalamic–pituitary–adrenal axis (HPA) activity differs ...
Ghrelin Indirectly Activates Hypophysiotropic CRF Neurons in Rodents
(Public Library of Science, 2012-02)
Ghrelin is a stomach-derived hormone that regulates food intake and neuroendocrine function by acting on its receptor, GHSR (Growth Hormone Secretagogue Receptor). Recent evidence indicates that a key function of ghrelin ...
Methamphetamine Induces TET1- and TET3-Dependent DNA Hydroxymethylation of Crh and Avp Genes in the Rat Nucleus Accumbens
(Humana Press, 2017-08)
Methamphetamine (METH) addiction is a biopsychosocial disorder that is accompanied by multiple relapses even after prolonged abstinence, suggesting the possibilities of long-lasting maladaptive epigenetic changes in the ...
α-MSH and γ-MSH modulate early release of hypothalamic PGE2 and NO induced by IL-1β differently
(Elsevier Ireland, 2006-12)
Interleukin-1beta (IL-1beta) stimulates corticotropin-releasing hormone (CRH) secretion in hypothalamus, which involves the release of prostaglandins (PGE2) and nitric oxide (NO). We have demonstrated that melanocortins ...