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Cholinergic transmission underlies modulation of frustration by open field exposure
(Pergamon-Elsevier Science Ltd, 2016-01)
Frustration can be defined as an emotional state generated by the omission or devaluation in the quantity or quality of an expected appetitive reward. Thus, reactivity to a reward is affected by prior experience with the ...
Nonneuronal cholinergic system in breast tumors and dendritic cells: does it improve or worsen the response to tumor?
(Hindawi Publishing Corporation, 2013-10)
Besides being the main neurotransmitter in the parasympathetic nervous system, acetylcholine (ACh) can act as a signaling molecule in nonneuronal tissues. For this reason, ACh and the enzymes that synthesize and degrade ...
Cholinergic drugs as therapeutic tools in inflammatory diseases: participation of neuronal and non-neuronal cholinergic systems
(Betham, 2013-08)
Acetylcholine (ACh) is synthesized by choline acetyltransferase (ChAT) from acetylcoenzime A and choline. This reaction occurs not only in pre-ganglionic fibers of the autonomic nervous system and post-ganglionic parasympathetic ...
Treatment with dexamethasone alters yawning behavior induced by cholinergic but not dopaminergic agonist
(Elsevier B.V., 1999-01-15)
Because stressful manipulations have been reported to modify drug-induced yawning, the present study investigated the effects of single and repeated treatment with a synthetic glucocorticoid, dexamethasone (DEXA) on ...
Participation of the cholinergic system in the ethanol-induced suppression of paradoxical sleep in rats
(Associação Brasileira de Divulgação Científica, 2008-09-01)
Sleep disturbance is among the many consequences of ethanol abuse in both humans and rodents. Ethanol consumption can reduce REM or paradoxical sleep (PS) in humans and rats, respectively. The first aim of this study was ...
Pharmacotherapies for Parkinson’s disease symptoms related to cholinergic degeneration
(Informa Healthcare, 2016-10)
Introduction: Dopamine depletion is one of the most important features of Parkinson’s Disease (PD). However, insufficient response to dopaminergic replacement therapy suggests the involvement of other neurotransmitter ...
Role of cholinergic, opioidergic and GABAergic neurotransmission of the dorsal hippocampus in the modulation of nociception in guinea pigs
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
Aims: Several physiological, pharmacological and behavioral lines of evidence suggest that the hippocampal formation is involved in nociception. The hippocampus is also believed to play an important role in the affective ...
Calcitonin modifies ligand binding to muscarinic receptor in CNS membranes
(Elsevier Science, 2000-03)
Calcitonin (CT) is a peptide produced by the thyroid gland, whose best described role is to prevent bone reabsorption, though it also participates in other biological functions through both central and peripheral mechanisms. ...