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Cell cycle dynamics of mouse embryonic stem cells in the ground state and during transition to formative pluripotency
(Nature Publishing Group, 2019-05)
Mouse embryonic stem cells (mESCs) can be maintained as homogeneous populations in the ground state of pluripotency. Release from this state in minimal conditions allows to obtain cells that resemble those of the early ...
Characterization of cellular states of CHO-K1 suspension cell culture through cell cycle and RNA-sequencing profiling
(Elsevier Science, 2018-11)
Chinese hamster ovary (CHO) derived cell lines are the preferred host system for the production of therapeutic proteins. The aim of this work was to explore the regulation of suspension-adapted CHO-K1 host cell line ...
Hexachlorobenzene alters cell cycle by regulating p27-cyclin E-CDK2 and c-Src-p27 protein complexes
(Elsevier Ireland, 2017-03)
Hexachlorobenzene (HCB) is an organochlorine pollutant widely distributed in the environment around the entire world. Previous reports from our group and others have demonstrated that this compound is as an endocrine ...
Targeting the cardiomyocyte cell cycle for heart regeneration
(Bentham Science Publishers, 2018-08)
Adult mammalian cardiomyocytes (CMs) exhibit limited proliferative capacity, as cell cycle activity leads to an increase in DNA content, but mitosis and cytokinesis are infrequent. This makes the heart highly inefficient ...
The Cell Cycle Inhibitors p21 Cip1 and p27 Kip1 Control Proliferation but Enhance DNA Damage Resistance of Glioma Stem Cells
(Elsevier, 2017-07)
High-grade gliomas are the most prevalent and lethal primary brain tumors. They display a hierarchical arrangement with a population of self-renewing and highly tumorigenic cells called cancer stemcells. These cells are ...
Regulation of cyclin E1 expression in human pluripotent stem cells and derived neural progeny
(Landes Bioscience, 2018-07)
Human pluripotent stem cells (hPSCs), including embryonic and induced pluripotent stem cells (hESCs and hiPSCs) show unique cell cycle characteristics, such as a short doubling time due to an abbreviated G1 phase. Whether ...
Potential use of ellagic acid for endometriosis treatment: its effect on a human endometrial cell cycle, adhesion and migration
(Royal Society of Chemistry, 2020-04)
Endometriosis is a common and challenging condition of reproductive-aged women that is defined as the presence of endometrial-like tissue outside the uterine cavity. Despite its prevalence, there is still no effective ...
Evidence for CRK3 participation in the cell division cycle of Trypanosoma cruzi
(Elsevier Science, 2002-12)
Trypanosoma cruzi CRK3 gene encodes a Cdc2p related protein kinase (CRK). To establish if it has a role in the regulation of the parasite cell cycle we studied CRK3 expression and activity throughout three life cycle stages. ...
Characterization of cellular types during the etrous cycle of the Myocastor Coypos (COYPU)
(International Fur Animal Scientific Association, 2009-12)
NO DISPONIBLE
G2/M cell cycle arrest and tumor selective apoptosis of acute leukemia cells by a promising benzophenone thiosemicarbazone compound
(Public Library of Science, 2015-06)
Anti-mitotic therapies have been considered a hallmark in strategies against abnormally proliferating cells. Focusing on the extensively studied family of thiosemicarbazone (TSC) compounds, we have previously identified ...