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Miro1 as a novel regulator of hypertrophy in neonatal rat cardiomyocytes
(Elsevier, 2020)
Cardiac hypertrophy is an adaptive response to manage an excessive cardiac workload and maintain normal cardiac function. However, sustained hypertrophy leads to cardiomyopathy, cardiac failure, and death. Adrenergic ...
Resistance to cardiomyocyte hypertrophy in ae3−/− mice, deficient in the AE3 Cl− /HCO3 − exchanger
(Biomed Central, 2014-07)
Background: Cardiac hypertrophy is central to the etiology of heart failure. Understanding the molecular pathways promoting cardiac hypertrophy may identify new targets for therapeutic intervention. Sodium-proton exchanger ...
AMPK signaling pathway is rapidly activated by T3 and regulates the cardiomyocyte growth
(North Holland PublishingLimerick, 2013-08-25)
Previous studies have indicated that AMP-activated protein kinase (AMPK) plays a critical role in the control of cardiac hypertrophy mediated by different stimuli such as thyroid hormone (TH). Although the classical effects ...
Fibrosis and hypertrophy induced by Trypanosoma cruzi in a three-dimensional cardiomyocyte-culture system
(Oxford University Press, 2019)
The Histone Demethylase JMJD2A Modulates the Induction of Hypertrophy Markers in iPSC-Derived Cardiomyocytes
(Frontiers in Genetics, 2018-02-09)
The development of cardiovascular pathologies is partly attributed to epigenetic causes, including histone methylation, which appears to be an important marker in hearts that develop cardiac hypertrophy. Previous studies ...
Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy
(BioMed Research International, 2016-09-18)
Epigenetic changes induced by histone demethylases play an important role in differentiation and pathological changes in cardiac cells. However, the role of the jumonji family of demethylases in the development of cardiac ...
GDF11 Modulates Ca2+-Dependent Smad2/3 signaling to prevent cardiomyocyte hypertrophy
(MDPI, 2018-05)
Growth differentiation factor 11 (GDF11), a member of the transforming growth factor- family, has been shown to act as a negative regulator in cardiac hypertrophy. Ca2+ signaling modulates cardiomyocyte growth; however, ...
Polycystin-1 is required for insulin-like growth factor 1-induced cardiomyocyte hypertrophy
(Public Library Science, 2021)
Cardiac hypertrophy is the result of responses to various physiological or pathological stimuli. Recently, we showed that polycystin-1 participates in cardiomyocyte hypertrophy elicited by pressure overload and mechanical ...
Angiotensin type 1 receptor mediates thyroid hormone-induced cardiomyocyte hypertrophy through the Akt/GSK-3 beta/mTOR signaling pathway
(DR DIETRICH STEINKOPFF VERLAG, 2009)
Several studies have implicated the renin angiotensin system in the cardiac hypertrophy induced by thyroid hormone. However, whether Angiotensin type 1 receptor (AT(1)R) is critically required to the development of ...