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New insights into bacterial bile resistance mechanisms: the role of bile salt hydrolase and its impact on human health
(Elsevier Science, 2018-10)
Bile acids (BA), the major components of bile, are biological detergents that facilitate the emulsification and solubilization of dietary lipids and also display potent antimicrobial activity, the bacterial membranes being ...
Effect of Cynara scolymus and Silybum marianum extracts on bile production in pigs
(Garuda Scientific Publications, 2018-01)
Many of the beneficial effects on productive performance observed when vegetable extracts are incorporated as feed additives in intensive farming can be explained by an increase in bile production. An experiment was conducted ...
Aquaporin gene therapy for cholestasis
(John Wiley & Sons Inc, 2017-01)
This is regarding the editorial “Aquaporin gene therapy for disorders of cholestasis?” by Tradtrantip and Verkman.(1) We thank the authors for their comments in our recent studies.(2,3) Nevertheless, we believe that an ...
Bile acids: Lipase-catalyzed synthesis of new hyodeoxycholic acid derivatives
(Elsevier Science Inc, 2018-12)
In this work we present an efficient, environmentally friendly approach to the synthesis of a series of hyodeoxycholic acid derivatives applying Biocatalysis. Fifteen acetyl and ester derivatives, twelve of them new, were ...
Vagally-mediates cholestatic and choleretic effects of centrally applied Endothelin-1 through ETA receptors
(Elsevier Science, 2006-12)
The role of Endothelin-1 (ET-1) in the central nervous system is not fully understood yet although several studies strongly support its neuromodulatory role. A high density of endothelin receptors is present in the dorsal ...
Antifouling activity of peracetylated cholic acid, a natural bile acid derivative
(Elsevier Science Inc, 2019-09)
The antifouling activity of peracetylated cholic acid (1), a bile acid derivative which was isolated in a previous work as a natural product from the Patagonian sponge Siphonochalina fortis, was evaluated in laboratory and ...
Hepatic bile formation: Canalicular osmolarity and paracellular and transcellular water flow
(American Society for Pharmacology and Experimental Therapeutics, 2019-12)
The purpose of this minireview is to show that a new paradigm is developing regarding hepatic bile flow. The focus thus far has been on carrier-mediated transport of bile acids and other solutes, such as glutathione, which ...
Molecular mechanisms triggered by bile acids on intestinal Ca2+absorption
(Bentham Science Publishers, 2018-10)
Background: Bile acids (BAs) are among the main components of bile. Lately, they are also considered important signaling molecules, not only by regulating their own synthesis, but also having a role in several metabolic ...
Biliary secretion and hepatic oxidative stress in animals fed with linoleic acid conjugates (CLA)
(Sociedad Argentina de Nutrición, 2008-12)
The purpose of this work was to investigate the effects of CLA at two levels (7 and 20%) of dietary fat on biliary secretion and oxidative stress in liver of rats. Animals were divided in four groups and fed with diets, ...
Dynamic Localization of Hepatocellular Transporters: Role in Biliary Excretion and Impairment in Cholestasis
(Bentham Science Publishers, 2017-12)
Bile acids, synthesized by hepatocytes from cholesterol, are specific and quantitatively important organic components of bile, where they are the main driving force of the osmotic process that generates bile flow toward ...