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Cytogenetic effect of 5-azacytidine in patients with hematological malignancies
(Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular, 2011-10-01)
BACKGROUND: Recently, the importance of cytogenetics has grown in the diagnosis, prognosis and treatment of leukemias and myelodysplastic syndromes. 5-azacytidine is a drug that has well-known cytogenetical effects and is ...
Chromosome damage induced by 5-azacytidine under the influence of caffeine or cytosine arabinoside in CHO-K1 (wild-type) and XRS-5 (mutant) cell lines
(2001-07-14)
5-azacytidine (5-azaC) treatment combined with cytosine arabinoside (ara-C) or caffeine were performed in vitro in Chinese hamster cells, CHO-K1 (wild-type) and xrs-5 (mutant) cell lines, in order to compare the cell ...
Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms
(Nature Publishing GroupLondonInglaterra, 2014)
Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer
(Nature Publishing Group, 2017-12)
Aberrant DNA methylation observed in cancer can provide survival benefits to cells by silencing genes essential for anti-tumor activity. DNA-demethylating agents such as Decitabine (DAC)/Azacitidine (AZA) activate otherwise ...
Accesibilidad de herramientas diagnóstico- terapéuticas para los pacientes con síndromes mielodisplásicos en la República ArgentinaAccess to diagnostic and therapeutic tools for myelodysplastic syndromes in Argentina
(Sociedad Argentina de Hematologia, 2017-05)
Los síndromes mielodisplásicos (SMD) constituyen un grupo heterogéneo de enfermedades hematológicas clonales cuya confirmación diagnóstica requierede un equipo interdisciplinario para la evaluación clínica, la descripción ...