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QSAR Study and Molecular Design of Open-Chain Enaminones as Anticonvulsant Agents
(Molecular Diversity Preservation International, 2011-09)
Present work employs the QSAR formalism to predict the ED50 anticonvulsant activity of ringed-enaminones, in order to apply these relationships for the prediction of unknown open-chain compounds containing the same types ...
Anticonvulsant effect of sodium cyclamate and propylparaben on pentylenetetrazol-induced seizures in zebrafish
(Wiley-liss, Div John Wiley & Sons Inc, 2017-04)
Screening for novel anticonvulsant drugs requires appropriate animal seizure models. Zebrafish provide small, accessible, and cost-efficient preclinical models applicable to high-throughput small molecule screening. Based ...
Cysticercosis of the central nervous system: How should it be managed?
(Wolters Kluwer Health, 2011)
Purpose of Review: Taenia solium neurocysticercosis (NCC) has been long recognized as an important cause of neurological morbidity in most of the world. Unwarranted generalization of diagnostic and treatment recommendations ...
SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF N-BENZOYL-TRYPTAMINE AND ITS NEW ANALOGUE N-SALICYLOYLTRYPTAMINE, A POTENTIAL ANTICONVULSANT AGENT
(Sociedad Chilena de Química, 2006)
QSAR and 3D-QSAR studies applied to compounds with anticonvulsant activity
(Informa Healthcare, 2014-10-09)
Quantitative structure--activity relationships (QSAR and 3D-QSAR) have been applied in the last decade to obtain a reliable statistical model for the prediction of the anticonvulsant activities of new chemical entities. ...
Searching for New Leads to Treat Epilepsy: Target-Based Virtual Screening for the Discovery of Anticonvulsant Agents
(American Chemical Society, 2018-07)
The purpose of this investigation is to contribute to the development of new anticonvulsant drugs to treat patients with refractory epilepsy. We applied a virtual screening protocol that involved the search into molecular ...