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Síntese, elucidação estrutural, avaliação da interação com DNA, atividades antiproliferativa e anti-topoisomerase de novos derivados de Acridina
(Universidade Federal de PernambucoUFPEBrasilPrograma de Pos Graduacao em Biologia Aplicada a Saude, 2016)
Identification of transcriptomic responses related to normal, healthy and accelerated aging
(Universidad del RosarioDoctorado en Ciencias BiomédicasFacultad de Ciencias Naturales y Matemáticas, 2018)
Aging is defined as the reduction in the physiological and adaptive capabilities of organisms with the passage of time. The accumulation of DNA damage could be the central event on which other factors related to the aging ...
Isolating and characterizing antimicrobial peptides derived from larvae of the blowfly Sarconesiopsis magellanica (diptera: Calliphoridae)
Larval therapy (LT) is an alternative treatment which uses fly larvae to heal chronic wounds; its action is based on debridement, bacterial removal and stimulating granulation tissue. The most important mechanism for ...
Identificación de señales de selección natural en genes de Plasmodium vivax que codifican proteínas involucradas en el proceso de invasión para determinar su potencial uso en una vacuna antimalárica
(Universidad del RosarioDoctorado en Ciencias Biomédicas y BiológicasFacultad de Ciencias Naturales y Matemáticas, 2019)
Plasmodium vivax, an endoparasite that arose in Asia and spread around the world, has biomedical importance given that it is the second most important human-malaria parasite. Although efforts have been made to reduce the ...
Tratamiento antitumoral basado en la expresión de la proteína NIS: Análisis del microambiente tumoral en un modelo in vitro
The sodium/iodide symporter (NIS) mediates iodide uptake in the thyroid. Since decades, NIS-mediated iodide uptake is a very useful tool for radioactive ablation of thyroid cancer cells. NIS-based gene therapy is a promising ...
Genómica funcional y disección molecular de FOXD1 para la identificación de nuevos biomarcadores genéticos asociados a patologías de la reproducción de origen endometrial y placentario
(Universidad del RosarioDoctorado en Ciencias BiomédicasFacultad de Ciencias Naturales y Matemáticas, 2018)
Recurrent pregnancy loss (RPL) is defined as the loss of two or more consecutive and spontaneous miscarriages before the 20th week of gestation. This pathology affects ~1% to 5% of the couples. The RPL aetiology is classified ...
Caracterización funcional del canal de potasio activado por calcio de conductancia intermedia (KCa3.1) en el endotelio de la córnea en condiciones fisiológicas y en ambientes hiperglúcidos
The cornea is the lens that protects the anterior surface of the eye and its transparent nature is a crucial part of the functioning of the eye. This characteristic is mainly determined by the activity of the cells of its ...