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Anidulafungin liposome nanoparticles exhibit antifungal activity against planktonic and biofilm Candida albicans
(2020-11-01)
Fungal infections can cause significant patient morbidity and mortality. Nanoparticle therapeutics have the potential to improve treatment of these infections. Here we report the development of liposomal nanoparticles ...
In vitro andulafungin susceptibility of 100 of Candida strains obtained previously to the introduction of this echinocandin in Chile Susceptibilidad in vitro a anidulafungina en 100 cepas de especies de Candida aisladas previo a la introducción de esta eq
(2011)
Fungi, particularly yeasts, have become important opportunistic pathogens that can be resistant to antifungal agents or develop resistance. To address this problem, new molecules such as echinocandins, have been developed. ...
Multicenter study of anidulafungin and micafungin MIC distributions and epidemiological cutoff values for eight candida species and the CLSI M27-A3 broth microdilution method
(American Society for Microbiology, 2014)
Since epidemiological cutoff values (ECVs) using CLSI MICs from multiple laboratories are not available for Candida spp. and the echinocandins, we established ECVs for anidulafungin and micafungin on the basis of wild-type ...
Antifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris
(Oxford University Press, 2019-05)
BACKGROUND: Candida auris is an emerging MDR pathogen. It shows reduced susceptibility to azole drugs and, in some strains, high amphotericin B MICs have been described. For these reasons, echinocandins were proposed as ...
Antifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris
(Journal of Antimicrobial ChemotherapyReino Unido, 2019-05-12)
Background: Candida auris is an emerging MDR pathogen. It shows reduced susceptibility to azole drugs and, in some strains, high amphotericin B MICs have been described. For these reasons, echinocandins were proposed as ...
Epidemiology of Candidemia in Latin America: A Laboratory-Based Survey
(Public Library of Science, 2013)
Background: The epidemiology of candidemia varies depending on the geographic region. Little is known about the epidemiology of candidemia in Latin America. Methods: We conducted a 24-month laboratory-based survey of ...
Comparative study of Candida spp. isolates: Identification and echinocandin susceptibility in isolates obtained from blood cultures in 15 hospitals in Medellín, Colombia
Objectives: Invasive candidiasis has a high impact on morbidity and mortality in hospitalised patients. Accurate and timely methods for identification of Candida spp. and determination of echinocandin susceptibility have ...
Candida species: Current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options
(2013-01-01)
The incidence of fungal infections has increased significantly, so contributing to morbidity and mortality. This is caused by an increase in antimicrobial resistance and the restricted number of antifungal drugs, which ...
Improved Detection of Candida spp. fks Hot Spot Mutants by Using the Method of the CLSI M27-A3 Document with the Addition of Bovine Serum Albumin
(American Society For Microbiology, 2011-03)
Echinocandins are highly bound to serum proteins, altering their antifungal properties. The addition of 50% human serum to the MIC assay improves the identification of echinocandin-resistant Candida spp. harboring fks hot ...
Species distribution and antifungal susceptibility profile of Candida isolates from bloodstream infections in Lima, Peru
(Microbiology Society, 2014)
Yeast identification and in vitro susceptibility testing provide helpful information for appropriate administration of antifungal treatments; however, few reports from the Latin American region have been published. The aim ...